Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

Basit Öğe Kaydı
dc.contributor.authorKöprülü, Tuğba Kul
dc.contributor.authorÖkten, Salih
dc.contributor.authorTekin, Şaban
dc.contributor.authorÇakmak, Osman
dc.date.accessioned2020-06-25T18:34:17Z
dc.date.available2020-06-25T18:34:17Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionOkten, Salih/0000-0001-9656-1803; Kul Koprulu, Tugba/0000-0001-9451-5715
dc.description.abstractDue to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma KurumuTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T394]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 112T394; Scientific and Technological Research Council of Turkeyen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/jbt.22260
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue3en_US
dc.identifier.pmid30431695
dc.identifier.scopus2-s2.0-85056753749
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22260
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7852
dc.identifier.volume33en_US
dc.identifier.wosWOS:000460550900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biochemical And Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectcancer cellsen_US
dc.subjectcytotoxic activityen_US
dc.subjectnitroquinolineen_US
dc.subjectphenylquinolineen_US
dc.subjectquinolinesen_US
dc.titleBiological evaluation of some quinoline derivatives with different functional groups as anticancer agentsen_US
dc.typeArticle

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