The effectiveness of organic vegetable oils with high biocompatibility in preventing epidural fibrosis: An experimental study

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dc.authoridKUL, Oguz/0000-0002-1282-650X
dc.authoridAkgun, Mehmet Yigit/0000-0003-1342-7663
dc.contributor.authorAkgul, Mehmet Huseyin
dc.contributor.authorAkgun, Mehmet Yigit
dc.contributor.authorAnteplioglu, Tugce
dc.contributor.authorKul, Oguz
dc.date.accessioned2025-01-21T16:45:22Z
dc.date.available2025-01-21T16:45:22Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and purpose - Epidural fibrosis after all spinal surgeries is an important surgical issue. Various biological and non-biological materials have been tried to inhibit epidural fibrosis, which is deemed to be the most important cause of pain after spinal surgery. Olive oil, nigella sativa oil and soybean oil employed in oral nutrition in clinics involving liquid fatty acids, palmatic acid, linoleic acid, stearic acid and palmitoleic acid. The effectiveness of olive oil, nigella sativa oil and soybean oil on epidural fibrosis was researched on for the first time in laminecto- my model. Methods - Fifty adult male Wistar albino rats weighing between 300 and 400 grams were used in the research. A total of 5 groups were formed: sham (Group I) (n = 10), no application was created; Group II (n = 10) 1 cc saline; Group III (n = 10) 1 cc olive oil; Group IV (n = 10) 1 cc nigella sativa oil; Group V (n = 10); 1 cc soybean oil was applied topically to the epidural region after laminectomy. The total spine of the rats was dissected, histopathological and immunochemical measurements were conducted. Neuro-histopathological results were scored semi-quantitatively in terms of vascular modification, neuron degeneration, gliosis and bleeding criteria.Results - The lowest level of fibrosis and connective tissue proliferation was observed in the group where nigella sativa oil was used after the operation, followed by the group treated with olive oil and lastly with the group given soybean oil.Conclusion - Nigella sativa oil and olive oil are very efficient for lowering the degree of epidural fibrosis and adhesions following laminectomy and can be employed as a sim- ple, inexpensive and highly biocompatible material in clinical practice.
dc.identifier.doi10.18071/isz.76.0379
dc.identifier.issn0019-1442
dc.identifier.issn2498-6208
dc.identifier.issue11-12
dc.identifier.pmid38051691
dc.identifier.scopus2-s2.0-85178850503
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.18071/isz.76.0379
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25629
dc.identifier.volume76
dc.identifier.wosWOS:001130770300008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLiteratura Medica
dc.relation.ispartofIdeggyogyaszati Szemle-Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectepidural fibrosis; laminectomy; nigella sativa; olive oil; soybean oil
dc.titleThe effectiveness of organic vegetable oils with high biocompatibility in preventing epidural fibrosis: An experimental study
dc.title.alternativeA magas biokompatibilitású szerves növényi olajok hatékonysága az epiduralis fibrosis megel?zésében: Kísérleti tanulmány
dc.typeArticle

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