Short-term effect of latanoprost on ocular circulation in ocular hypertension

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dc.contributor.authorAkarsu, C
dc.contributor.authorBilgili, YK
dc.contributor.authorTaner, P
dc.contributor.authorUnal, B
dc.contributor.authorErgin, A
dc.date.accessioned2020-06-25T17:40:05Z
dc.date.available2020-06-25T17:40:05Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description4th International Glaucoma Symposium -- MAR 19-22, 2003 -- Barcelona, SPAIN
dc.description.abstractPurpose: To determine the short-term effects of latanoprost on retrobulbar circulation in ocular hypertension. Methods: Forty-six eyes of 23 consecutive bilateral ocular hypertensive patients with an intraocular pressure (IOP) of greater than 22 mmHg were evaluated in a prospective controlled study. All subjects received a single drop of latanoprost 0.005% in one eye and placebo in the fellow control eye. Systemic circulatory parameters, intraocular pressure, blood flow velocities, and resistance indices of the ophthalmic, short posterior ciliary and central retinal arteries were measured using colour Doppler imaging at baseline and 2 h and 8 h after dosing, Results: Latanoprost lowered IOP significantly after 2 h and 8 h (P < 0.01). The mean IOP reduction was 6.7 mmHg 8 h after dosing. At baseline, there were no statistically significant differences in any retrobulbar vessels of eyes that received a single drop of latanoprost when compared with the eyes that received placebo (P > 0.05). Comparisons with baseline and latanoprost conditions revealed that latanoprost did not alter the blood flow velocities and resistance indices in the ophthalmic (P > 0.05), posterior ciliary (P > 0.05) and central retinal (P > 0.05) arteries 2 h and 8 h after dosing. The systolic and diastolic blood pressures (P = 0.74, P = 0.29, respectively) and pulse rate (P = 0.68) remained unchanged over the 8-h period. Conclusions: This study found that a single drop of latanoprost significantly reduces intraocular pressure 8 h after dosing. However, it does not have any short-term effects on the retrobulbar haemodynamics in ocular hypertensive eyes.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1442-9071.2004.00840.x
dc.identifier.endpage377en_US
dc.identifier.issn1442-6404
dc.identifier.issue4en_US
dc.identifier.pmid15281970
dc.identifier.scopus2-s2.0-4444344514
dc.identifier.scopusqualityQ1
dc.identifier.startpage373en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-9071.2004.00840.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3253
dc.identifier.volume32en_US
dc.identifier.wosWOS:000223473200008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Asiaen_US
dc.relation.ispartofClinical And Experimental Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcolour Doppler imagingen_US
dc.subjectintraocular pressureen_US
dc.subjectlatanoprosten_US
dc.subjectretrobulbar haemodynamicsen_US
dc.titleShort-term effect of latanoprost on ocular circulation in ocular hypertensionen_US
dc.typeArticle

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