Expression profile and prognostic importance in prostate lesions of the reverse transcriptase component of human telomerase (hTERT) and of cyclin-dependent kinase inhibitor p57 (p57kip2a)

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dc.contributor.authorAtasoy, Pınar
dc.contributor.authorYılmaz, Erdal
dc.contributor.authorBozdoğan, Önder
dc.contributor.authorAyva, Şebnem
dc.contributor.authorBatislam, Ertan
dc.date.accessioned2020-06-25T17:48:34Z
dc.date.available2020-06-25T17:48:34Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractTo investigate expression of the reverse transcriptase component of human telomerase (hTERT) and of cyclin-dependent kinase inhibitor p57 (p57(kip2a)) in prostate neoplasms and evaluate the relationship between these proteins and the Gleason score. hTERT and p57(kip2a) antibodies were studied by immunohistochemical methods in 70 prostate adenocarcinomas (33 high-grade and 37 low-grade carcinomas), 29 benign prostate hyperplasias, and 19 prostatic intraepithelial neoplasias (PIN). Only nuclear staining was evaluated with p57(kip2a) whereas both nuclear and nucleolar staining were evaluated with hTERT. Immunohistochemical histologic scores (HSCOREs) of hTERT were significantly higher in the PIN group than in the hyperplasia group (P = 0.03). hTERT HSCOREs were not significantly different between hyperplasias and carcinomas or between low and high-grade carcinomas. p57(kip2a) HSCOREs were significantly higher in hyperplasias than other groups, and in PINS than carcinomas, but did not differ significantly between low and high-grade carcinomas. A significant negative correlation was observed between hTERT and p57(kip2a) (P = 0.007) in the hyperplasia group. No such correlation was found in PINs and carcinomas. This study suggests that p57(kip2a) is down-regulated in the malignant side of the spectrum of prostate carcinogenesis. Loss of p57(kip2a) control on hTERT might have an important role in the development of prostate cancer.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s11255-008-9399-7
dc.identifier.endpage60en_US
dc.identifier.issn0301-1623
dc.identifier.issue1en_US
dc.identifier.pmid18521717
dc.identifier.scopus2-s2.0-62349121283
dc.identifier.scopusqualityQ2
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-008-9399-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4495
dc.identifier.volume41en_US
dc.identifier.wosWOS:000263508000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology And Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGleason scoreen_US
dc.subjecthTERTen_US
dc.subjectp57(kip2a)en_US
dc.subjectProstate lesionsen_US
dc.titleExpression profile and prognostic importance in prostate lesions of the reverse transcriptase component of human telomerase (hTERT) and of cyclin-dependent kinase inhibitor p57 (p57kip2a)en_US
dc.typeArticle

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