Perioperative intravenous adenosine infusion to extend postoperative analgesia in brachial plexus block

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dc.contributor.authorApan, A.
dc.contributor.authorÖzcan, S.
dc.contributor.authorBüyükkocak, Ü.
dc.contributor.authorAnbarci, O.
dc.contributor.authorBasar, H.
dc.date.accessioned2020-06-25T17:35:15Z
dc.date.available2020-06-25T17:35:15Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and objective: Adenosine infusions have been shown to reduce requirements of anaesthetics, to decrease the need for postoperative analgesics and to attenuate hyperaesthesia related to neuropathic pain. We decided to investigate the effects, beneficial or otherwise, of an adenosine infusion administered during surgery. A brachial plexus block was used to produce anaesthesia for the surgery. Methods: Sixty adults undergoing upper extremity surgery were included in the study. Brachial plexus block was performed via an axillary approach with lidocaine 1.25 % and epinephrine 1/200 000 (40 mL). Patients were randomly assigned to two groups. During surgery, saline (control) or adenosine 80 mug kg min was infused intravenously in a double-blind fashion for 1 h. Visual analogue scores every 4 h, analgesic consumption, time to first spontaneous pain sensation, time to first rescue analgesic and adverse effects were noted during the first 24 h. Results: Vital signs were stable in both groups throughout surgery. During the adenosine infusion, one patient fainted while another complained of palpitations and tightness of the chest; both patients were excluded from further analyses. The time to first sensation of pain was significantly longer in the adenosine group compared to the control group (438 +/- 387 vs. 290 +/- 227 min, P = 0.02). The time to first rescue analgesic, the visual analogue scale scores and analgesic consumption in the postoperative period were similar. Conclusions: In patients undergoing surgery with an axillary plexus block, a perioperative adenosine infusion prolongs the duration of postoperative analgesia to some extent. However, the time to first rescue analgesic, total analgesic requirements and pain scores were unchanged; the risk of potentially serious adverse effects is high. This therapy cannot be recommended.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/00003643-200311000-00010
dc.identifier.endpage919en_US
dc.identifier.issn0265-0215
dc.identifier.issn1365-2346
dc.identifier.issue11en_US
dc.identifier.pmid14649345
dc.identifier.scopus2-s2.0-0242473848
dc.identifier.scopusqualityQ1
dc.identifier.startpage916en_US
dc.identifier.urihttps://doi.org/10.1097/00003643-200311000-00010
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3072
dc.identifier.volume20en_US
dc.identifier.wosWOS:000186676100010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal Of Anaesthesiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectANAESTHESIA, CONDUCTION, nerve blocken_US
dc.subjectbrachial plexusen_US
dc.subjectNEUROTRANSMITTERS, adenosineen_US
dc.subjectPOSTOPERATIVE COMPLICATIONS, painen_US
dc.subjectSPINAL NERVES, brachial plexusen_US
dc.titlePerioperative intravenous adenosine infusion to extend postoperative analgesia in brachial plexus blocken_US
dc.typeArticle

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