Effect of trapidil in ischemia/reperfusion injury of peripheral nerves

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dc.contributor.authorBagdatoglu, C.
dc.contributor.authorSaray, A.
dc.contributor.authorSürücü, H.S.
dc.contributor.authorÖztürk, H.
dc.contributor.authorTamer, L.
dc.date.accessioned2020-06-25T17:35:01Z
dc.date.available2020-06-25T17:35:01Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.descriptionBAGDATOGLU, CELAL/0000-0002-4237-9288; SURUCU, HUSEYIN SELCUK/0000-0002-9244-4236
dc.description.abstractOBJECTIVE: Ischemia plays an important role in the development of pathological changes in nerve tissue, and restoration of blood flow results in injury (ischemia/ reperfusion [I/R] injury) mediated by toxic oxygen free radicals. Trapidil is currently used as a coronary artery vasodilating agent and is also used for the prevention of ischemic symptoms of cerebral vasospasm. The purpose of this study was to determine the effects of trapidil on I/R injury and the ischemic tolerance of rat peripheral nerves. METHODS: Preischemia or prereperfusion administration of trapidil (8 mg/kg) was evaluated in the rat sciatic nerve I/R injury model. Nerve tissue samples from the I/R injury site were assayed for malondialdehyde (MDA), nitrites, and nitrates, as markers of I/R injury, and pathological changes were evaluated by electron microscopy. RESULTS: I/R resulted in an increase in MDA levels, which remained elevated for 2 weeks in control nerves. Rats that received trapidil before ischemia exhibited decreased MDA levels, and rats that received trapidil after the standard 3 hours of ischemia demonstrated increased tolerance to reperfusion, as reflected in significantly decreased MDA levels. Nitrite and nitrate levels in trapidil-treated rats were significantly higher than those in control animals. Histological evaluations of the sciatic nerve segments demonstrated that preischemia and postischemia trapidil treatments had a sparing effect against the myelin damage and axonal edema that are consistently noted in untreated ischemic reperfused nerves. CONCLUSION: The results confirm that pretreatment with trapidil before the ischemic insult or before reperfusion provides marked protection against I/R injury in peripheral nerves.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/00006123-200207000-00031
dc.identifier.endpage219en_US
dc.identifier.issn0148-396X
dc.identifier.issn1524-4040
dc.identifier.issue1en_US
dc.identifier.pmid12182420
dc.identifier.scopus2-s2.0-0036664765
dc.identifier.scopusqualityQ1
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.1097/00006123-200207000-00031
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2992
dc.identifier.volume51en_US
dc.identifier.wosWOS:000176611700046
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofNeurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia/reperfusion injuryen_US
dc.subjectperipheral nerveen_US
dc.subjecttrapidilen_US
dc.subjecttwo-way analysis of varianceen_US
dc.titleEffect of trapidil in ischemia/reperfusion injury of peripheral nervesen_US
dc.typeArticle

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