Effects of Intracisternal and Intravenous Dexmedetomidine on Ischemia-Induced Brain Injury in Rat: A Comparative Study

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dc.contributor.authorKöse, Emine Arzu
dc.contributor.authorBakar, Bülent
dc.contributor.authorKasımcan, Ömür
dc.contributor.authorAtilla, Pergin
dc.contributor.authorKılınç, Kamer
dc.contributor.authorMuftuoğlu, Sevda
dc.contributor.authorApan, Alpaslan
dc.date.accessioned2020-06-25T18:07:26Z
dc.date.available2020-06-25T18:07:26Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionATILLA, PERGIN/0000-0001-5132-0002
dc.description.abstractAIM: To compare the effect of dexmedetomidine administered by intracisternal route with by intravenous route on brain tissue of rat after incomplete cerebral ischemia. MATERIAL and METHODS: Cerebral ischemia was produced by the combination of right common carotid artery occlusion and hemorrhagic hypotension during 30 minutes. Thirty minutes before the ischemia, 0.1 ml 0.9% NaCl (Group SIC, n=6) or 9 mu g/kg dexmedetomidine (Group DIC, n=6) was administered into the cisterna magna. For the intravenous groups, 9 mu g/kg dexmedetomidine (Group DIV, n=6) or 0.9% NaCl (Group CONTROL, n=6) 5 ml/kg/h was given in 2 hours. After 24 hours, the lipid peroxidation levels were measured in the brain tissue and plasma. Hippocampal formations were used for histopathological examination. RESULTS: Intravenous dexmedetomidine produced a decrease in baseline mean arterial blood pressure and plasma glucose concentrations. There was a significant difference between the DIV group and DIC, SIC, CONTROL groups regarding the brain lipid peroxidation levels (p<0.001, p<0.001, p=0.001, respectively), and regarding the picnotic neuronal cell count (p<0.001, p=0.01, p=0.009, respectively). Mean plasma lipid peroxidation levels of the DIV group was different from the DIC group (p=0.003). CONCLUSION: Systemically administered dexmedetomidine had neuroprotective effect in ischemia-induced neuronal damage, but centrally administered dexmedetomidine did not.en_US
dc.identifier.citationKose, E. A., Bakar, B., Kasimcan, O., Atilla, P., Kılınç, K., Muftuoglu, S., ... Apan, A.(2013). Effects of Intracisternal and Intravenous Dexmedetomidine on Ischemia-Induced Brain Injury in Rat: A Comparative Study. TURKISH NEUROSURGERY , vol.23, no.2, 208-217en_US
dc.identifier.doi10.5137/1019-5149.JTN.6757-12.0
dc.identifier.endpage217en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.pmid23546907
dc.identifier.scopus2-s2.0-84875818523
dc.identifier.scopusqualityQ3
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.6757-12.0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5574
dc.identifier.volume23en_US
dc.identifier.wosWOS:000317375900013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectIntracisternalen_US
dc.subjectIntravenousen_US
dc.subjectIschemiaen_US
dc.subjectBrain injuryen_US
dc.titleEffects of Intracisternal and Intravenous Dexmedetomidine on Ischemia-Induced Brain Injury in Rat: A Comparative Studyen_US
dc.typeArticle

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