Augmentation of post transplant immunity: antigen encounter at the time of hematopoietic stem cell transplantation enhances antigen-specific donor T-cell responses in the post transplant repertoire

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dc.contributor.authorMori, S.
dc.contributor.authorKoçak, U.
dc.contributor.authorShaw, J. L.
dc.contributor.authorMullen, C. A.
dc.date.accessioned2020-06-25T17:40:41Z
dc.date.available2020-06-25T17:40:41Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAfter transplant, the immune system is reconstituted by cells derived from both hematopoietic stem cells and peripheral expansion from differentiated donor T cells. After transplant, immune function is poor despite transplantation of mature lymphocytes from immune-competent donors. We tested the hypothesis that early antigen encounter at the time of cell transplant would improve the desired donor T- cell responses. Two independent models of peptide-specific T- cell responses were studied. The model for CD4 cells employed T cells from transgenic ( Tg) DO11.11 mice that constitutively express the T- cell receptor for the class II- restricted ovalbumin peptide 323 - 339. The model for CD8 cells employed non-Tg H2- Db- restricted T- cell responses to the influenza nucleoprotein peptide 366 - 374. As measured both functionally and by direct imaging of T cells using clonotypic reagents, encounter with specific antigen at the time of T- cell transplantation led to clonal expansion of donor T cells and preservation of donor T- cell function in the post transplant immune environment. Antigen- specific donor T- cell function was poor if antigen encounter was delayed or omitted. Severe parent > F1 graft- versus- host reactions blocked the effect of early antigen exposure. Vaccination of transplant recipients against microbial or leukemia antigens may be worthy of study.en_US
dc.description.sponsorshipNCI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [5T32CA073954-05, 1 R01 CA10628-01]en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1038/sj.bmt.1704883
dc.identifier.endpage801en_US
dc.identifier.issn0268-3369
dc.identifier.issn1476-5365
dc.identifier.issue8en_US
dc.identifier.pmid15750607
dc.identifier.scopus2-s2.0-18144413563
dc.identifier.scopusqualityQ1
dc.identifier.startpage793en_US
dc.identifier.urihttps://doi.org/10.1038/sj.bmt.1704883
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3521
dc.identifier.volume35en_US
dc.identifier.wosWOS:000228146800009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofBone Marrow Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthematopoietic stem cell transplantationen_US
dc.subjectT cellen_US
dc.subjectvaccinationen_US
dc.subjectimmunityen_US
dc.titleAugmentation of post transplant immunity: antigen encounter at the time of hematopoietic stem cell transplantation enhances antigen-specific donor T-cell responses in the post transplant repertoireen_US
dc.typeArticle

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