Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field
Yükleniyor...
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice. Material and methods: MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose of 60 mg/kg. A total of 48 locally bred adult female mice 25 - 35 g in weight were used. Latency to seizure, total seizure duration, and mortality were recorded for each mouse. Results: Neither pre- nor post-drug exposure to a 50 Hz, 0.2 mT MF was found to have any effect on PTZ-induced epileptic seizures or mortality rates in mice. Conclusion: The present study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT MF for epilepsy.
Açıklama
Anahtar Kelimeler
50 Hz, extremely low frequency (ELF), magnetic field (MF), epilepsy, pentylenetetrazol (PTZ)
Kaynak
International Journal Of Radiation Biology
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
83
Sayı
4
Künye
closedAccess
