Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field

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dc.contributor.authorCanseven, Ayşe G.
dc.contributor.authorKeskil, Zuhal Aktuna
dc.contributor.authorKeskil, Semih
dc.contributor.authorSeyhan, Nesrin
dc.date.accessioned2020-06-25T17:43:52Z
dc.date.available2020-06-25T17:43:52Z
dc.date.issued2007
dc.description.abstractPurpose: To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice. Material and methods: MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose of 60 mg/kg. A total of 48 locally bred adult female mice 25 - 35 g in weight were used. Latency to seizure, total seizure duration, and mortality were recorded for each mouse. Results: Neither pre- nor post-drug exposure to a 50 Hz, 0.2 mT MF was found to have any effect on PTZ-induced epileptic seizures or mortality rates in mice. Conclusion: The present study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT MF for epilepsy.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/09553000701206676
dc.identifier.endpage235en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue4en_US
dc.identifier.pmid17575950
dc.identifier.scopus2-s2.0-33947119188
dc.identifier.scopusqualityQ2
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org10.1080/09553000701206676
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3931
dc.identifier.volume83en_US
dc.identifier.wosWOS:000246068200003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Radiation Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject50 Hzen_US
dc.subjectextremely low frequency (ELF)en_US
dc.subjectmagnetic field (MF)en_US
dc.subjectepilepsyen_US
dc.subjectpentylenetetrazol (PTZ)en_US
dc.titlePentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic fielden_US
dc.typeArticle

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