Investigation of the effects of enteral hormones on the pyloric muscle in newborn rats

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dc.contributor.authorBoybeyi, Ozlem
dc.contributor.authorSoyer, Tutku
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorGunal, Yasemin Dere
dc.contributor.authorAslan, Mustafa Kemal
dc.date.accessioned2020-06-25T18:15:42Z
dc.date.available2020-06-25T18:15:42Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionSoyer, Tutku/0000-0003-1505-6042
dc.description.abstractPurpose: To investigate the effects of enteral hormones on pyloric muscle in order to clarify the etiopathogenesis of hypertrophic pyloric stenosis (HPS). Methods: Forty-two newborn Wistar-Albino rats were included. No intervention was done in the control group (CG, n = 6). In the sham group (SG, n = 6) 1 ml saline (0.9% NaCl solution), in the Nw-nitro-L-arginine methyl ester hydrochloride (L-NAME) group (LNG, n = 6) 100 mg/kg/d L-NAME, in the somatostatin group (STG, n = 6) 7 mcg/kg/d ST, in the cholecystokinin group (CCKG, n = 6) 3 mcg/kg/d CCK, in the substance P group (SPG, n = 6) 5 ml/kg/d SP, and in the prostaglandin-E1 group (PGE1G, n = 6) a cumulative dose of 360 mcg/kg PGE1 was given intraperitoneally for 14 days. On the 21st day, histopathological examination and muscle thickness measurements were done. Results were evaluated statistically. Results: Total and circular pyloric muscle thicknesses were significantly increased in the LNG compared to the CG and SG (p < 0.05). Circular pyloric muscle thickness was not increased in the STG, CCKG and SPG compared to the CG and SG (p > 0.05). In the PGE1G, muscle thickness was significantly decreased in the pylorus and increased in the antrum compared to the CG and SG (p < 0.05). Conclusion: Nitric oxide synthase (NOS) inhibition with L-NAME seems to be a causative factor in HPS by increasing pyloric muscle thickness. PGE predominantly affects antral gastric muscle and has no profound effect on pyloric muscle. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipKirikkale University Scientific Research CouncilKirikkale University [2013/61]en_US
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Council (2013/61). Special thanks go to Mrs. Corrine Can for her kind contribution to the English revision of the manuscript.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jpedsurg.2014.05.036
dc.identifier.endpage412en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue3en_US
dc.identifier.pmid25746698
dc.identifier.scopus2-s2.0-84924054741
dc.identifier.scopusqualityQ1
dc.identifier.startpage408en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2014.05.036
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6224
dc.identifier.volume50en_US
dc.identifier.wosWOS:000350825200009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypertrophic pyloric stenosisen_US
dc.subjectPyloric muscleen_US
dc.subjectEnteral hormonesen_US
dc.subjectL-NAMEen_US
dc.subjectProstaglandinen_US
dc.titleInvestigation of the effects of enteral hormones on the pyloric muscle in newborn ratsen_US
dc.typeArticle

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