Effect of glucosamine chondroitine sulphate on repaired tenotomized rat Achilles tendons

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dc.contributor.authorOzer, Hamza
dc.contributor.authorTaskesen, Anil
dc.contributor.authorKul, Oguz
dc.contributor.authorSelek, Hakan Y.
dc.contributor.authorTuranli, Sacit
dc.contributor.authorKose, Kenan
dc.date.accessioned2020-06-25T17:52:13Z
dc.date.available2020-06-25T17:52:13Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We evaluated the effects of glucosamine chondroitine sulphate (glcN-CS) on rat Achilles tendons in this experimental animal study. Materials and methods: Thirty Wistar albino type rats weighing 300-350 g were randomly grouped into two. Group A: Achilles tendons were tenotomized, repaired and, glcN-CS given orally. Group B: Achilles tendons were tenotomized and repaired. All the rats were fed with pellet chow. Five rats in each group were sacrificed at 4, 8, and 12 weeks interval. Tensile strength of three tendon specimen from each group were tested biomechanically and two specimen were analysed histopathologically via immunohistochemical staining and hematoxylin and eosin staining. Contralateral side Achilles tendons were also grouped and analyzed as controls (group C and D). Results: Histological results showed well organized collagen formation and less inflammation in group A. Biomechanical testing showed higher tendon strength in group A at eight weeks which is not statisticaly significant (55.3 +/- 4.84N, p=0.078). Rats which were were given glcN-CS had greater tendon strength which is statisticaly significant (50.01 +/- 5.62, p=0.014). Conclusion: Glucoseamine chondroitine sulphate improved results of Achilles tendon healing in rats. This result might be due to decreased inflammation and stimulation of collagen synthesis. Although glcN-CS is recommended only in osteoarthritic patients to relieve symptoms and signs it can also be prefered in treatment of soft tissue injuries formed during sports activities.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage106en_US
dc.identifier.issn1305-8282
dc.identifier.issn1309-0313
dc.identifier.issue2en_US
dc.identifier.pmid21762066
dc.identifier.scopus2-s2.0-80051968160
dc.identifier.scopusqualityN/A
dc.identifier.startpage100en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5110
dc.identifier.volume22en_US
dc.identifier.wosWOS:000293815300009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotr
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofEklem Hastaliklari Ve Cerrahisi-Joint Diseases And Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAchilles tendonen_US
dc.subjectinflammationen_US
dc.subjectglucoseamineen_US
dc.subjectprimary repairen_US
dc.titleEffect of glucosamine chondroitine sulphate on repaired tenotomized rat Achilles tendonsen_US
dc.typeArticle

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