Protective effect of aerobic exercise on the vocal folds against cigarette smoke exposure

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dc.contributor.authorUnlu, Ceren Ersoz
dc.contributor.authorAkkoca, Ozlem
dc.contributor.authorTatar, Ilkan
dc.contributor.authorSargon, Mustafa Fevzi
dc.contributor.authorZeybek, Dilara
dc.contributor.authorOguztuzun, Serpil
dc.date.accessioned2020-06-25T18:34:03Z
dc.date.available2020-06-25T18:34:03Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description39th Turkish National Congress of Otorhinolaryngology Head and Neck Surgery -- NOV 08-12, 2017 -- Antalya, TURKEY
dc.descriptionSargon, Mustafa Fevzi/0000-0001-6360-6008
dc.description.abstractPurposeLaryngeal pathologies due to cigarette smoking vary among individuals, whereas some smokers remain disease free. These differences can be explained by multiple factors among individuals. In this context, an animal study was designed to determine if there is any protective effect of aerobic exercise against the detrimental effects of cigarette smoke on laryngeal tissues.MethodsA total of 24 male Wistar albino rats were divided into three groups of eight animals each: control (no smoke exposure), smoking (smoke exposure), and exercise (smoke exposure and exercise) groups. Histopathological (light and electron microscopy) and immunohistochemical (GSTA1, CYP1A1, CYP2E1) evaluations of the vocal folds were performed at the end of experimental period.ResultsExercise group revealed statistically significant decrease in edema (p=0.03) and inflammatory cell infiltration (p=0.02) compared to smoking group. In electron microscopic evaluation; cytoplasmic vacuoles were also present in exercise group, but were smaller than smoking group. Edema and swollen mitochondria were also less prominent in exercise group. Condensed chromatin material in the periphery of nucleus was observed only in few cells in exercise group, and observed in more cells in smoking group. GSTA1 expression was higher (p=0.047) and CYP1A1 expression was lower (p=0.01) in exercise group than smoking group.ConclusionsOur results indicate that aerobic exercise has a protective role on the larynx against the damaging effect of cigarette smoke. Smokers who exercise regularly may be at a lower risk of cigarette smoke-related laryngeal diseases, as compared with those who do not exercise.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00405-019-05422-8
dc.identifier.endpage1719en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue6en_US
dc.identifier.pmid30980189
dc.identifier.scopus2-s2.0-85064267055
dc.identifier.scopusqualityQ1
dc.identifier.startpage1713en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-019-05422-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7777
dc.identifier.volume276en_US
dc.identifier.wosWOS:000468590200021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAerobic exerciseen_US
dc.subjectRaten_US
dc.subjectSmokeen_US
dc.subjectVocal folden_US
dc.titleProtective effect of aerobic exercise on the vocal folds against cigarette smoke exposureen_US
dc.typeArticle

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