CAG polymorphism in the androgen receptor gene in women may be associated with nodulocystic acne

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dc.contributor.authorDemirkan, Serkan
dc.contributor.authorSayin, Derya Beyza
dc.contributor.authorGunduz, Ozgur
dc.date.accessioned2020-06-25T18:34:34Z
dc.date.available2020-06-25T18:34:34Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionGunduz, Ozgur/0000-0003-1021-5219
dc.description.abstractIntroduction: Acne vulgaris (AV) is a multifactorial, inflammatory disease of the pilosebaceous unit. Hormones play a major role in the pathogenesis of acne. In cases of hyperandrogenism; hirsutism, acne, seborrhoea and alopecia appear in women. However, severe acne can also be seen without evidence of hyperandrogenism. In this case, hypersensitivity of the androgen receptor gene (ARG) encoded in the X chromosome, which is the only receptor for androgens, can be considered. ARG contains a polymorphic CAG triple loop encoding the polyglutamine pathway at the 5'end of exon 1. Aim: To investigate CAG repeat polymorphism in the ARG in nodulocystic acne patients in Turkish population. Material and methods: This prospective clinical study was conducted between 2016 and 2017 in accordance with the tenets of the Declaration of Helsinki. DNA isolation from blood was performed using the RTA (R) Genomic DNA Isolation Kit. The fragment lengths obtained from the device to determine CAG repeat numbers were analysed based on -288 bp length 22 CAG repeat content. Results: A total of 199 subjects; 100 patients (51 males, 49 females) and 99 controls (49 males, 50 females) were included in the study. The mean allele length in the patient group was 19.34; and 19.7 in the control group. There was a statistically significant difference between female patients and the control group, when the patients and control groups were compared by gender (p = 0.0059). Conclusions: The CAG trinucleotide repeat count in the ARG may be associated with acne, without hirsutism findings.en_US
dc.description.sponsorshipKirikkale University Scientific Research Project Support Coordination Uniten_US
dc.description.sponsorshipThis study was carried out with the support of the Kirikkale University Scientific Research Project Support Coordination Unit.en_US
dc.identifier.citationDemirkan, S., Sayın, D., & Gündüz, Ö. (2019). CAG polymorphism in the androgen receptor gene in women may be associated with nodulocystic acne. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 36(2), 173-176.en_US
dc.identifier.doi10.5114/ada.2019.84592
dc.identifier.endpage176en_US
dc.identifier.issn1642-395X
dc.identifier.issue2en_US
dc.identifier.pmid31320850
dc.identifier.scopus2-s2.0-85066086058
dc.identifier.scopusqualityQ2
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.5114/ada.2019.84592
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7959
dc.identifier.volume36en_US
dc.identifier.wosWOS:000467799900007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofPostepy Dermatologii I Alergologii
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacneen_US
dc.subjectpolymorphismen_US
dc.subjectandrogen receptor geneen_US
dc.subjectCAGen_US
dc.titleCAG polymorphism in the androgen receptor gene in women may be associated with nodulocystic acneen_US
dc.typeArticle

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