Oxidative stress markers in young patients with polycystic ovary syndrome, the relationship between insulin resistances

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dc.contributor.authorKaradeniz, M.
dc.contributor.authorErdogan, M.
dc.contributor.authorTamsel, S.
dc.contributor.authorZengi, A.
dc.contributor.authorAlper, G. E.
dc.contributor.authorCaglayan, O.
dc.contributor.authorYilmaz, C.
dc.date.accessioned2020-06-25T17:44:46Z
dc.date.available2020-06-25T17:44:46Z
dc.date.issued2008
dc.descriptionkaradeniz, muammer/0000-0002-3345-5437
dc.description.abstractObjective: Polycystic ovary syndrome is a syndrome of ovarian dysfunction. Oxidative stress, inflammation and endothelial cell activation are thought to play concomitant roles in the pathogenesis of the above diseases particularly in the development of atherosclerotic lesions. Research Design and Methods: We studied 58 polycystic ovary syndrome patients and age-matched 25 healthy controls consisting of women that have regular, ovulatory cycles and normal androgen levels. Homeostasis Model Assessment-Insulin Resistance for this study was taken as 1.75 that is the upper level of confidence interval of %95 of the mean of the healthy group. PCOS patients were divided into two groups as for below the cut-off level (< 1.75) and above the cut-off level (>= 1.75). hs-CRP, fibrinogen, malondialdehyde, nitric oxide and disulfide level results were compared both in PCOS and control groups. Results: In this study, sensitive CRP was found to be statical significantly higher in polycystic ovary syndrome groups whose Homeostasis Model Assessment-Insulin Resistance were >= 1.75 and < 1.75 when compared to the control group. But, no significantly correlation was determined between malondialdehyde, nitric oxide and disulfide levels and CRP elevation. Conclusions: In our study, because those participants were young and non-obese patients with PCOS, malondialdehyde, nitric oxide and disulfide levels and Carotid Artery Intima-Media Thickness measurements as a pre-indicator of cardiovascular disease were not found to be different from those of the controls.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-2007-992154
dc.identifier.endpage235en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue4en_US
dc.identifier.pmid18393129
dc.identifier.scopus2-s2.0-42649105135
dc.identifier.scopusqualityQ2
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org10.1055/s-2007-992154
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4192
dc.identifier.volume116en_US
dc.identifier.wosWOS:000255837900007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbhen_US
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectoxidative stress markersen_US
dc.subjectcardiovascular risk managementen_US
dc.titleOxidative stress markers in young patients with polycystic ovary syndrome, the relationship between insulin resistancesen_US
dc.typeArticle

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