The Healing Effects of Thymoquinone and Dexpanthenol in Sciatic Nerve Compression Injury in Rats

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dc.contributor.authorOgden, Mustafa
dc.contributor.authorKaraca, Sahika Burcu
dc.contributor.authorAydin, Gulcin
dc.contributor.authorYuksel, Ulas
dc.contributor.authorDagli, Ahmet Turan
dc.contributor.authorAkkaya, Suleyman
dc.contributor.authorBakar, Bulent
dc.date.accessioned2020-06-25T18:30:43Z
dc.date.available2020-06-25T18:30:43Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionBAKAR, BULENT/0000-0002-6236-7647
dc.description.abstractIntroduction: Functional healing of peripheral nerve injuries is still difficult. In this study, potential healing effects of thymoquinone and dexpanthenol in sciatic nerve compression injury (SCI) were investigated. Method: Twenty-four male Wistar albino rats which were applied compression injury to their sciatic nerves were randomly separated into four groups as following: "control" group contained six rats administered no pharmacological agent; "TMK" group consisted of six rats administered 10 mg/kg intraperitoneal thymoquinone once a day for one week; "DXP" group contained six rats administered 50 mg/kg intraperitoneal dexpanthenol once a day for one week; and "TMK-DXP" group consisted of six rats administered separately 10 mg/kg intraperitoneal thymoquinone and 50 mg/kg intraperitoneal dexpenthanol once a day for one week. Four weeks later from SCI, sciatic nerve function index (SFI) was applied before sacrifice of all rats, and then their crushed sciatic nerves were histopathologically examined, in terms of "Schwann cell count", "axon and myelin degeneration", "axon shape/size differences", "fibrosis", and "neovascularisation". Results: "Schwann cell count" (p = 0.011), "axon and myelin degeneration" (p = 0.001), "axon shape/size differences" (p = 0.011), and "fibrosis and neovascularisation" (p = 0.026) scores were different between the control and TMK-DXP groups. SFI scores were different between the control and TMK groups (p = 0.002), between the control and TMK-DXP groups (p < 0.001), and between the DXP and TMK-DXP groups (p = 0.029). Conclusions: This study results revealed that these pharmacological agents used alone had no histopathological healing effect in rats with SCI, but thymoquinone could improve walking function. However, thymoquinone and dexpanthenol used together had a significant histopathological and functional healing effect.en_US
dc.description.sponsorshipScientific Research Projects Co-ordination Unit of Kirikkale UniversityKirikkale University [2014/98]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Co-ordination Unit of Kirikkale University (Project No: 2014/98).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/08941939.2019.1658831
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.pmid31462122
dc.identifier.scopus2-s2.0-85071337433
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/08941939.2019.1658831
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7709
dc.identifier.wosWOS:000484634600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsciatic nerveen_US
dc.subjectcompression injuryen_US
dc.subjectthymoquinoneen_US
dc.subjectdexpanthenolen_US
dc.titleThe Healing Effects of Thymoquinone and Dexpanthenol in Sciatic Nerve Compression Injury in Ratsen_US
dc.typeArticle

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