Novel hydrogel membrane based on copoly(hydroxyethyl methacrylate/p-vinylbenzylpoly(ethylene oxide)) for biomedical applications: Properties and drug release characteristics

Basit Öğe Kaydı
dc.contributor.authorArıca, M. Yakup
dc.contributor.authorBayramoğlu, Gülay
dc.contributor.authorArıca, Betül
dc.contributor.authorYalçın, Emine
dc.contributor.authorIto, Koichi
dc.contributor.authorYağcı, Yusuf
dc.date.accessioned2020-06-25T17:40:22Z
dc.date.available2020-06-25T17:40:22Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study was to synthesize and characterize a novel biocompatible polymeric membrane system and demonstrate its potential use in various biomedical applications. Synthetic hydrogels based on poly(hydroxyethyl methacrylate), poly(HEMA), have been widely studied and used in biomedical fields. A novel copolymer hydrogel was prepared in the membrane form using 2-hydroxyethyl methacrylate monomer (HEMA) and a macromonomer p-vinylbenzyl-poly(ethylene oxide) (V-PEO) via photoinitiated polymerization. A series of poly(HEMA/V-PEO) copolymer membranes with different compositions were prepared. The membranes were characterised using infrared, thermal and SEM analysis. The thermal stabilities of the copolymer membranes were found to be lowered by an increase in the ratio of macromonomer (V-PEO) in the membrane structure. Because of the incorporation of PEO segments, the coplymers exhibited significantly higher hydropholic surface properties than pure poly(HEMA), as demonstrated by contact angle measurements. Equilibrium swelling studies were conducted to investigate the swelling behavior of the membrane. The equilibrium water uptake was reached in about 4 h. Moreover, the blood protein adsorption and platelet adhesion were significantly reduced on the surface of the PEO contacting copolymer membranes compared to control pure poly(HEMA). Drug release experiments were performed in a continuous release system using model drug (vancomycin) loaded copoly(HEMA/V-PEO) membrane formulation possessing the highest PEO contact (with a HEMA:V-PEO (mmol:mmol) feed ratio of 112:1 and loaded with 40 mg antibiotic/g polymer) released and can be considered as a potential candidate for a transdermal antibiotic carrier and various biomedical and biotechological applications.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/mabi.200500091
dc.identifier.endpage992en_US
dc.identifier.issn1616-5187
dc.identifier.issue10en_US
dc.identifier.pmid16208632
dc.identifier.scopus2-s2.0-27544453537
dc.identifier.scopusqualityQ1
dc.identifier.startpage983en_US
dc.identifier.urihttps://doi.org/10.1002/mabi.200500091
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3410
dc.identifier.volume5en_US
dc.identifier.wosWOS:000233002900008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofMacromolecular Bioscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadsorptionen_US
dc.subjectcontrolled releaseen_US
dc.subjecthydrogelsen_US
dc.subjectmembranesen_US
dc.subjectthermal analysisen_US
dc.titleNovel hydrogel membrane based on copoly(hydroxyethyl methacrylate/p-vinylbenzylpoly(ethylene oxide)) for biomedical applications: Properties and drug release characteristicsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Novel hydrogel membrane based on copoly.pdf
Boyut:
194.5 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu