FAS, FAS ligand, tumor infiltrating lymphocytes, and macrophages in malignant melanoma: an immunohistochemical study

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dc.contributor.authorBozdoğan, Nazan
dc.contributor.authorBozdoğan, Önder
dc.contributor.authorPak, Işın
dc.contributor.authorAtasoy, Pınar
dc.date.accessioned2020-06-25T17:49:25Z
dc.date.available2020-06-25T17:49:25Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground FAS and its ligand, FASL, have important roles in the neoplasia-immunity relationship. In melanoma, the importance of FAS and FASL remains controversial, despite a group of studies. In this study, we aimed to demonstrate the distribution of FAS/FASL in melanotic lesions and to investigate the correlation between tumor infiltrating lymphocytes and macrophages. Methods Ten intra-dermal nevi, 12 primary malignant melanoma, and eight skin and 15 lymph node metastases were included in this study. FAS and FASL were studied in all of the groups using classical labeled streptavidin-biotin immunohistochemical method. Tumor infiltrating lymphocyte status and macrophage number demonstrated by CD68 immunostain were also evaluated in primary melanoma and skin metastases. Results FAS positivity was detected in all of the cases. FASL expressions were seen in 60% of the intra-dermal nevus and in all of the other groups. There were significant differences in FASL between nevus and primary melanoma, nevus and skin metastasis, and nevus and lymph node metastasis. There were strong positive correlations between FAS expression and intra-neoplastic macrophage score and between FASL and density of lymphocyte infiltration in skin metastases. Conclusion Although FAS and FASL expression is a constant feature of melanotic lesions, its diagnostic importance is very limited because of the different results obtained in the past studies. The correlation between FAS status and macrophage number and between FASL status and lymphocyte number in skin metastasis but not in primary lesions might point to diverse FAS/FASL interaction between neoplastic cells and macrophages in the different microenvironments.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage767en_US
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.issue7en_US
dc.identifier.pmid20618494
dc.identifier.scopus2-s2.0-77954170643
dc.identifier.scopusqualityQ1
dc.identifier.startpage761en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4712
dc.identifier.volume49en_US
dc.identifier.wosWOS:000279022400005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleFAS, FAS ligand, tumor infiltrating lymphocytes, and macrophages in malignant melanoma: an immunohistochemical studyen_US
dc.typeArticle

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