Tumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement

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dc.contributor.authorGuven, Orhan
dc.contributor.authorTekin, Umut
dc.contributor.authorSalmanoglu, Berrin
dc.contributor.authorKaymak, Emre
dc.date.accessioned2020-06-25T18:15:55Z
dc.date.available2020-06-25T18:15:55Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionSALMANOGLU, BERRIN/0000-0003-4344-5782
dc.description.abstractPurpose: The purpose of this study was to investigate the level of tumor necrosis factor-alpha (TNF-alpha) in the synovial fluid (SF) of patients with temporomandibular joint (TMJ) internal derangement and to show the relationship between the level of TNF-alpha and the severity of the disease. Materials and methods: Arthrocentesis was performed on 32 female and five male patients (aged between 17 and 45) referred to our clinic with the complaint of TMJ pain and discomfort. TNF-alpha levels were determined in the SF samples obtained during arthrocentesis. As a measure of pain, visual analog scale (VAS) scores were also evaluated. Results: There were statistically significant differences in VAS scores between the stages. VAS scores were found to be elevated as the stage of disease progressed. Increased levels of TNF-alpha were found in progressive stages of internal derangement. Conclusion: In our study, both SF TNF-alpha levels and pain levels (VAS scores) were found to be increased in patients with internal derangement as the stage of the disease progresses. TNF-alpha might contribute to the pathogenesis of synovitis and the degeneration of the TMJ cartilage and bone. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jcms.2014.10.017
dc.identifier.endpage105en_US
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.issue1en_US
dc.identifier.pmid25465487
dc.identifier.scopus2-s2.0-84919640047
dc.identifier.scopusqualityQ1
dc.identifier.startpage102en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcms.2014.10.017
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6342
dc.identifier.volume43en_US
dc.identifier.wosWOS:000346833400018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal Of Cranio-Maxillofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInternal derangementen_US
dc.subjectProinflammatory cytokinesen_US
dc.subjectTMJen_US
dc.subjectTNF-alphaen_US
dc.titleTumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangementen_US
dc.typeArticle

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