Protective effect of adrenomedullin on contrast induced nephropathy in rats

Basit Öğe Kaydı
dc.contributor.authorİnal, Salih
dc.contributor.authorKoç, Eyüp
dc.contributor.authorUlusal-Okyay, Gülay
dc.contributor.authorPaşaoglu, Özge T.
dc.contributor.authorIsik-Gonul, İpek
dc.contributor.authorOz-Oyar, Eser
dc.contributor.authorGüz, Galip
dc.date.accessioned2020-06-25T18:12:33Z
dc.date.available2020-06-25T18:12:33Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and aims: Contrast-induced nephropathy (CIN) has a growing incidence in which renal vasoconstriction and medullary hypoxia are important mechanisms. Therapeutic approaches are very restricted and there is a considerable interest in advancing preventive strategies. Adrenomedullin is a relatively novel peptide having antioxidant, vasoactive and vasodilatory properties. We aimed to investigate whether adrenomedullin might have a preventive role against the development of experimental CIN. Methods: Wistar albino rats (n=24) were allocated randomly into four equal groups of 6 each; Control (C), Adrenomedullin (A), Contrast Media (CM) and Adrenomedullin plus Contrast Media (ACM). All rats were deprived of water from day 1 to day 4 during 72 hours. Then, intravenous administrations of chemicals were performed. Adrenomedullin was given at dose of 12 mu g/kg to groups A and ACM. A single dose of high-osmolar contrast media; diatrizoate (Urografin 76%, Schering AG, Germany) was injected to groups CM and ACM at dose of 10mL/kg. On day 1 and 6 blood samples were drawn for renal function tests and inflammatory markers including TNF-alpha IL-1 beta, IL-6 and IL-18. After sacrification, kidney histologies were examined with hematoxylineosin staining. Results: Compared to CM group, serum cystatin-C levels on 6th day were found significantly lower in ACM group (p<0.05). Additionally, daily protein excretion rates, absolute changes in daily urine output and creatinine clearance values were significantly lower in ACM group than those in CM group (p<0.05). In histopathological evaluation, regarding the degree of tubular damage and medullary congestion scores, ACM group had slightly better scores compared to CM group; however the differences did not reach significance as shown in inflammatory markers. Conclusion: This study demonstrated a beneficial impact of adrenomedullin on deteriorated renal function tests in an experimental CIN model. Adrenomedullin might be a candidate agent for prophylaxis of CIN. However, further studies are needed to shed more light on this issue.en_US
dc.identifier.citationInal, S., Koc, E., Ulusal-Okyay, G., Paşaoglu, Ö. T., IŞIK Gönül, İ., Oz-Oyar, E., ... Paşaoglu, H.(2014). Protective effect of adrenomedullin on contrast induced nephropathy in rats. NEFROLOGIA , vol.34, no.6, 724-731.en_US
dc.identifier.doi10.3265/Nefrologia.pre2014.Sep.12405
dc.identifier.endpage731en_US
dc.identifier.issn0211-6995
dc.identifier.issn1989-2284
dc.identifier.issue6en_US
dc.identifier.pmid25335086
dc.identifier.scopus2-s2.0-84911481481
dc.identifier.scopusqualityQ2
dc.identifier.startpage724en_US
dc.identifier.urihttps://doi.org/10.3265/Nefrologia.pre2014.Sep.12405
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5968
dc.identifier.volume34en_US
dc.identifier.wosWOS:000345564400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Espanola Nefrologia Dr Rafael Matesanzen_US
dc.relation.ispartofNefrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdrenomedullinen_US
dc.subjectContrast-induced nephropathyen_US
dc.subjectRadiocontrast mediaen_US
dc.subjectRat modelen_US
dc.titleProtective effect of adrenomedullin on contrast induced nephropathy in ratsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Protective effect of adrenomedullin on contrast induced nephropathy in rats.pdf
Boyut:
170.79 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu