Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis

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dc.contributor.authorKavut, Ayse Baccioglu
dc.contributor.authorKalpaklioglu, Fusun
dc.contributor.authorAtasoy, Pinar
dc.date.accessioned2020-06-25T18:07:51Z
dc.date.available2020-06-25T18:07:51Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: A neuroallergic interaction was reported in the pathogenesis of allergic rhinitis (AR), but the pathophysiology of nonallergic rhinitis (NAR) is poorly understood. We aimed to explore the contribution of neuroallergic mechanisms to the pathogenesis of NAR. Methods: Subjects were divided into three groups - NAR patients (n = 25), AR patients (n = 16) and the control group (n = 10) - and were assessed using the nasal provocation test (NPT) with house dust mite. Total symptom scores, nasal inspiratory peak flow and nasal lavage were performed before and after NPT. Nasal brushing and scraping was done after NPT. Results: NPT was positive in NAR (52%) and AR (100%) patients and negative in all controls. After NPT, total symptom scores increased in both rhinitis groups. Post-NPT values of nasal inspiratory peak flow decreased only in AR patients. NAR patients showed a similar inflammatory cell profile in the nasal smears to AR patients which was different in controls. There were more tryptase- and immunoglobulin E (IgE)-positive cells in the nasal mucosa of AR patients, and more substance-p-positive cells were observed in NAR patients compared with controls. However, IgE- and tryptase-positive cells in NAR patients and substance-p-positive cells in AR patients were detectable in nasal mucosa, but rarely in the controls. Comparing the values before and after NPT, tryptase significantly increased in the nasal lavages of AR and NAR patients, while house dust mite-specific IgE did not change. Conclusions: We showed the existence of a common pathophysiological mechanism with different contributions in AR and NAR. We conclude that the difference in dominance of neuroallergic ways may determine the major phenotype of rhinitis. Copyright (C) 2012 S. Karger AG, Baselen_US
dc.description.sponsorshipKirikkale University Projects of Scientific ResearchesKirikkale University [2007/4]en_US
dc.description.sponsorshipThis work was supported by a grant from Kirikkale University Projects of Scientific Researches (grant No. 2007/4) which was received by Baccioglu Kavut and Fusun Kalpaklioglu.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1159/000339739
dc.identifier.endpage191en_US
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.issue2en_US
dc.identifier.pmid23018649
dc.identifier.scopus2-s2.0-84872587966
dc.identifier.scopusqualityQ2
dc.identifier.startpage184en_US
dc.identifier.urihttps://doi.org/10.1159/000339739
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5674
dc.identifier.volume160en_US
dc.identifier.wosWOS:000311488700010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives Of Allergy And Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtopyen_US
dc.subjectAllergic rhinitisen_US
dc.subjectImmunoglobulin Een_US
dc.subjectImmunohystochemical stainingen_US
dc.subjectNasal provocationen_US
dc.subjectNeurogenic activationen_US
dc.subjectNonallergic rhinitisen_US
dc.subjectTryptaseen_US
dc.subjectSubstance pen_US
dc.titleContribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitisen_US
dc.typeArticle

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