The effect of danger-associated molecular patterns on survival in acute graft versus host disease

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dc.authoridKeklik, Muzaffer/0000-0002-6426-5249
dc.authoridKaynar, Leylagul/0000-0002-2035-9462
dc.authoridCelik, Serhat/0000-0002-1052-9800
dc.contributor.authorCelik, Serhat
dc.contributor.authorKaynar, Leylagul
dc.contributor.authorGuven, Zeynep Tugba
dc.contributor.authorDuran, Kubra Atasever
dc.contributor.authorKontas, Olgun
dc.contributor.authorKeklik, Muzaffer
dc.contributor.authorUnal, Ali
dc.date.accessioned2025-01-21T16:45:05Z
dc.date.available2025-01-21T16:45:05Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractDanger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopoietic stem cell transplantation (allo-HCT) and GvHD. We aimed to evaluate the effects of UA and Fib levels on survival in GvHD. One hundred seventy-four patients with grade 2-4 acute GvHD were included. UA and Fib levels were evaluated on allo-HCT day 0 and GvHD on days 0, 7, 14, and 28. Fib GvHD day 0 was the independent predictor for overall survival (OS), non-relapse mortality (NRM), and progression-free survival in multivariable models (HR 0.98, p < 0.001; HR 0.98, p = 0.001, HR 0.98, p = 0.006, respectively). Also UA GvHD day 28 was the independent predictor for OS and NRM (HR 0.77, p = 0.004; HR 0.76, p = 0.011, respectively). Our results indicated that hypouricemia and hypofibrinogenemia were associated with a significantly shorter OS and higher NRM. UA and Fib are remarkable molecules in GvHD because they are routinely utilized, readily available, can be therapeutic targets, and have DAMPs and antioxidant features.
dc.description.sponsorshipThe authors thank all the patients who participated in this study and all the doctors, nurses, staff and patient relatives in the clinic for their hard work for the patients.
dc.description.sponsorshipThe authors thank all the patients who participated in this study and all the doctors, nurses, staff and patient relatives in the clinic for their hard work for the patients.
dc.identifier.doi10.1038/s41409-023-02145-7
dc.identifier.endpage195
dc.identifier.issn0268-3369
dc.identifier.issn1476-5365
dc.identifier.issue2
dc.identifier.pmid37935781
dc.identifier.scopus2-s2.0-85175948564
dc.identifier.scopusqualityQ1
dc.identifier.startpage189
dc.identifier.urihttps://doi.org/10.1038/s41409-023-02145-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25586
dc.identifier.volume59
dc.identifier.wosWOS:001100593300003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBone Marrow Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.titleThe effect of danger-associated molecular patterns on survival in acute graft versus host disease
dc.typeArticle

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