A compendium answering 150 questions on COVID-19 and SARS-CoV-2

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dc.contributor.authorRiggioni, Carmen
dc.contributor.authorComberiati, Pasquale
dc.contributor.authorGiovannini, Mattia
dc.contributor.authorAgache, Ioana
dc.contributor.authorAkdis, Muebeccel
dc.contributor.authorAlves-Correia, Magna
dc.contributor.authorAnto, Josep M.
dc.date.accessioned2021-01-14T18:10:29Z
dc.date.available2021-01-14T18:10:29Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionJimenez-Saiz, Rodrigo/0000-0002-0606-3251; O'Mahony, Liam/0000-0003-4705-3583; Comberiati, Pasquale/0000-0001-5209-9733; O'Hehir, Robyn/0000-0002-3489-7595; de las Vecillas Sanchez, Leticia/0000-0003-4969-5678; RIGGIONI, CARMEN/0000-0002-8745-0228; Correia, Magna/0000-0002-7676-5558; AZKUR, DILEK/0000-0002-4396-9087
dc.description.abstractIn December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in similar to 9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.en_US
dc.description.sponsorshipEAACIen_US
dc.description.sponsorshipThe authors thank EAACI for the support to the Junior Member Assembly (JMA), the sections, interest groups, and working groups that enabled the generation of this paper. The authors recognize Dr Anna Globinska for graphic design and Dr Laura Alberch for a critical review of the manuscript.en_US
dc.identifier.citationRiggioni, C, Comberiati, P, Giovannini, M, et al. A compendium answering 150 questions on COVID-19 and SARS-CoV-2. Allergy. 2021; 75: 2503– 2541.en_US
dc.identifier.doi10.1111/all.14449
dc.identifier.endpage2541en_US
dc.identifier.issn0105-4538
dc.identifier.issn1398-9995
dc.identifier.issue10en_US
dc.identifier.pmid32535955
dc.identifier.scopus2-s2.0-85088247928
dc.identifier.scopusqualityQ1
dc.identifier.startpage2503en_US
dc.identifier.urihttps://doi.org/10.1111/all.14449
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12634
dc.identifier.volume75en_US
dc.identifier.wosWOS:000550399700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEYen_US
dc.relation.ispartofALLERGY
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectallergyen_US
dc.subjectcoronavirus disease 2019en_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectsevere acute respiratory syndrome-related coronavirus 2en_US
dc.titleA compendium answering 150 questions on COVID-19 and SARS-CoV-2en_US
dc.typeReview Article

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