The effect of the platelet-rich plasma on osteogenic potential of the periosteum in an animal bone defect model

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dc.authoridCirpar, Meric/0000-0001-9669-6513
dc.authoridCanbeyli, Ibrahim Deniz/0000-0003-3880-4779
dc.authoridSanli, Elif/0000-0002-9189-9781
dc.contributor.authorOktas, Birhan
dc.contributor.authorCirpar, Meric
dc.contributor.authorSanli, Elif
dc.contributor.authorCanbeyli, Ibrahim Deniz
dc.contributor.authorBozdogan, Onder
dc.date.accessioned2025-01-21T16:45:22Z
dc.date.available2025-01-21T16:45:22Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: This study aims to investigate whether plasma-rich plasma (PRP) enhances the osteogenic potential of periosteal grafts used to repair bone defects and maintains both histologically and biomechanically more durable bone tissue. Materials and methods: A standard bone defect was formed to the left femurs of 54 Sprague-Dawley rats and three groups were formed. In the first group (n=18), no periosteal repair was done for bone defect. In the second group (n=18), periosteal graft tissue was sutured to cover the defect entirely. In the third group (n=18), before periosteal repair, a 1 mL of PRP fibrin was applied into the bone defect. All femoral specimens were compared histologically at four and six weeks and biomechanically by three-point bending test at six weeks after treatment. Results: In the PRP applied group, healing of the bone defect at four weeks was significantly better than the other groups in terms of histological new bone formation (p<0.05). At six weeks, new bone formation in both of the periosteum preserved groups was superior to the first group (p<0.05, for both). There was no statistically significant difference between the second and third groups at the end of the sixth week in the biomechanical analysis, although both groups were significantly stronger than the first group (p<0.05). Conclusion: Stimulation of the periosteum with PRP application causes early osteogenic differentiation of precursor cells. Although, at biomechanical basis, PRP application does not create any significant difference, in the recovery of the bone defects at very early period, application of PRP may play a role to accelerate fracture and to decrease nonunions.
dc.identifier.doi10.52312/jdrs.2021.199
dc.identifier.endpage675
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue3
dc.identifier.pmid34842099
dc.identifier.scopus2-s2.0-85121229823
dc.identifier.scopusqualityQ2
dc.identifier.startpage668
dc.identifier.urihttps://doi.org/10.52312/jdrs.2021.199
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25624
dc.identifier.volume32
dc.identifier.wosWOS:000721982000015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectFracture healing; osteogenesis; periosteum; platelet-rich plasma
dc.titleThe effect of the platelet-rich plasma on osteogenic potential of the periosteum in an animal bone defect model
dc.typeArticle

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