Prevention of the harmful effects of free oxygen radicals by using N-acetylcysteine in testicular torsion

Basit Öğe Kaydı
dc.contributor.authorTangul, Sevgi Ulusoy
dc.contributor.authorCakmak, Ahmet Murat
dc.contributor.authorCaglayan, Osman
dc.contributor.authorBozdogan, Onder
dc.date.accessioned2021-01-14T18:10:52Z
dc.date.available2021-01-14T18:10:52Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractIntroduction Testicular torsion is a urological emergency both in childhood and in adult life. Many studies on experimental testicular torsion have demonstrated biochemical and pathological ischemia reperfusion injury and the efficacy of some drugs have been investigated to prevent this damage. N-acetylcysteine (NAC) promotes glutathione synthesis and acts as a glutathione precursor because of the fact that it increases the glutathione-reductase activity by transporting sulfhydryl groups. Aim In this experimental study, the authors aimed to investigate the effectiveness of NAC in preventing ischemia-reperfusion injury following testicular torsion and detorsion. Study design For this experimental study, 36 albino Wistar-male rats were used. The rats were randomly divided into 4 groups: sham (n = 8), ischemia-reperfusion (n = 8), ischemia-NAC -reperfusion (n = 10), and ischemia-NAC-reperfusionNAC (n = 10) groups. Two hours of torsion and 4 h of detorsion were created in the left testis. After 4 h of detorsion, the rats were sacrificed. Each tissue was divided into two sections for biochemical and pathological examinations. Results There was a statistically significant difference between the study groups in terms of the total-sulfhydryl level, nitric oxide level, and the malondialdehyde values. Histopathological examination revealed that NAC was effective in preventing reperfusion injury in the testis but ineffective in preventing the reduction in the spermatid count. Discussion The results of this experimental study support that NAC can histopathologically maintain the structure of seminiferous tubules against ischemis reperfusion injury and prevent damage to the germinative cells. However, it was unable to prevent the reduction in spermatid count. There was no significant difference in the prevention of ischemiareperfusion injury between NAC administration during the first hour of ischemia and NAC administration during reperfusion. Although NAC can prevent tissue damage from ischemia reperfusion injury, it is not effective against the reduction in the spermatid count. Conclusion N-acetylcysteine may be biochemically effective in preventing ischemia-reperfusion injury after testicular torsion and detorsion. NAC is a readily available and easy to use agent that can be used during testicular ischemia.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1016/j.jpurol.2019.10.028
dc.identifier.issn1477-5131
dc.identifier.issn1873-4898
dc.identifier.issue1en_US
dc.identifier.pmid31882389
dc.identifier.scopus2-s2.0-85077166964
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jpurol.2019.10.028
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12806
dc.identifier.volume16en_US
dc.identifier.wosWOS:000538165900018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC UROLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpermatic cord torsionen_US
dc.subjectTesticular torsionen_US
dc.subjectAcetylcysteineen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.titlePrevention of the harmful effects of free oxygen radicals by using N-acetylcysteine in testicular torsionen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
1-s2.0-S1477513119303717-main.pdf
Boyut:
1.32 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu