The effect of ischemia reperfusion on intestinal contractility regulated by the nitrergic system

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dc.contributor.authorCaglayan, F
dc.contributor.authorSahin, A
dc.contributor.authorGunel, E
dc.contributor.authorCakmak, M
dc.contributor.authorCaglayan, O
dc.date.accessioned2020-06-25T17:40:15Z
dc.date.available2020-06-25T17:40:15Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBecause of the interaction between nitric oxide (NO) and the superoxide anion radical, the effect of ischemia-reperfusion on intestinal contractility regulated by the nitrergic system was investigated in the present study. The study was performed on 3 groups of rabbits: group 1, ischemia; group 2, ischemia and 1 h of reperfusion; group 3, ischemia and 24 h of reperfusion. Tissue samples were obtained from ischemic, ischemia-reperfused and adjacent uninjured intestines as study and control samples. The effects of atropine, tetrodotoxin, L-NAME and L-arginine on the intestinal response to electrical field stimulation (EFS) were investigated. Guanethidine was used to minimize adrenergic activity. Tetrodotoxin and atropine prevented contractions. L-NAME enhanced the responses to EFS in all tissue samples except for the study tissue of group 2, and L-arginine reversed this contraction elevation. Group 2 study tissue response was as high as 170% of that of the control tissue in standard Krebs-Henseleit solution, and no change was seen on this level with L-NAME and L-arginine addition. The effects of tetrodotoxin and atropine revealed that EFS affects via the cholinergic neuronal system. Ischemia reperfusion affects intestinal contractility, especially in the early phases of reperfusion. In the light of the increased response to EFS and insensitivity to L-NAME and L-arginine of the affected tissue during this period it was thought that the nitrergic system is considerably affected by ischemia reperfusion. Excessive production of superoxide anion radicals or reversible inhibition of nitric oxide synthase may be the cause of this.en_US
dc.identifier.citationÇağlayan, F., Şahin, A. S., Günel, E., Çakmak, M., Çağlayan, O. (2004). The effect of ischemia reperfusion on intestinal contractility regulated by the nitrergic system. Turkish Journal of Veterinary and Animal Sciences, 28(5), 845 - 850.en_US
dc.identifier.endpage850en_US
dc.identifier.issn1300-0128
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-11844254509
dc.identifier.scopusqualityQ3
dc.identifier.startpage845en_US
dc.identifier.trdizinid37657
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3363
dc.identifier.volume28en_US
dc.identifier.wosWOS:000226210000010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherScientific Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Veterinary & Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectintestinal contractilityen_US
dc.subjectintestinal ischemia reperfusionen_US
dc.subjectL-arginineen_US
dc.subjectL-NAMEen_US
dc.subjectnitric oxideen_US
dc.titleThe effect of ischemia reperfusion on intestinal contractility regulated by the nitrergic systemen_US
dc.typeArticle

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