The Effect of Extractum Cepae, Heparin Sodium, and Allantoin in Experimental Peritoneal Adhesion

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dc.contributor.authorOzmen, Ismail
dc.contributor.authorGunal, Yasemin Dere
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorKisa, Ucler
dc.contributor.authorYorubulut, Serap
dc.contributor.authorAslan, Mustafa Kemal
dc.contributor.authorBoybeyi-Turer, Ozlem
dc.date.accessioned2021-01-14T18:10:41Z
dc.date.available2021-01-14T18:10:41Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractThe purpose of the study is to investigate the effects of extractum cepae (EC), heparin sodium (HS), and allantoin (AA) on postoperative peritoneal adhesion (PPA) prevention. Forty-eight rats were allocated into six groups (n = 8). PPA was performed by Harris method. In group 1, no additional procedure was done. Abdominal cavity was washed with normal saline in group 2, EC in group 3, HS in group 4, AA in group 5, and EC-HS-AA mixture (EHA-m) in group 6. On the 21st postoperative day, PPA was scored with Nair adhesion score and examined for fibrosis histopathologically and hydroxy-proline levels (OHP) biochemically. Macroscopically, PPA was decreased in groups 2, 4, and 6 compared to groups 1, 3, and 5 (p < 0.05) and decreased in group 2 compared to other groups (p < 0.05). Histopathologically, fibrosis was decreased in groups 2, 4, and 6 compared to other groups and decreased in group 2 compared to other groups (p < 0.05). Tissue OHP level was decreased in groups 2, 3, 4, and 5 compared to groups 1 and 6 (p < 0.05). Tissue OHP level was decreased in group 6 compared to group 1, but the difference was not statistically significant. PPA formation decreases with normal saline, HS and EHA-m, whereas increases with EC and AA both macroscopically and microscopically. Although HS and EHA-m seem to have adhesion prevention effect, washing the intestines with saline seems to be more effective.en_US
dc.description.sponsorshipKirikkale University Scientific Research CouncilKirikkale University [2014/81]en_US
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Council (2014/81) for only purchasing laboratory animal and other materials stated in the methods.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1007/s12262-020-02176-0
dc.identifier.endpage898en_US
dc.identifier.issn0972-2068
dc.identifier.issn0973-9793
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85084125316
dc.identifier.scopusqualityQ4
dc.identifier.startpage892en_US
dc.identifier.urihttps://doi.org/10.1007/s12262-020-02176-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12733
dc.identifier.volume82en_US
dc.identifier.wosWOS:000528311600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSPRINGER INDIAen_US
dc.relation.ispartofINDIAN JOURNAL OF SURGERY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeritoneal cavityen_US
dc.subjectTissue adhesionsen_US
dc.subjectAllantoinen_US
dc.subjectExtractum cepaeen_US
dc.subjectHeparinen_US
dc.titleThe Effect of Extractum Cepae, Heparin Sodium, and Allantoin in Experimental Peritoneal Adhesionen_US
dc.typeArticle

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