Remineralization effect of NaF, NaF with TCP, NaF with CPP-ACP and NaF with CXP varnishes on newly erupted first permanent molars: A randomized controlled trial

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dc.authoridErkmen Almaz, Merve/0000-0001-6766-2023
dc.contributor.authorAlmaz, Merve Erkmen
dc.contributor.authorUlusoy, Nur Burcu
dc.contributor.authorOba, Aylin Akbay
dc.contributor.authorDokumaci, Aysun
dc.date.accessioned2025-01-21T16:44:04Z
dc.date.available2025-01-21T16:44:04Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: The aim of this study was to evaluate the remineralization effect of NaF, NaF with TCP, NaF with CPP-ACP and NaF with CXP varnishes on newly erupted first permanent molars using laser fluorescence (LF) method. The study was a randomized, double- blind, controlled trial with four parallel groups.Methods: The study was carried out in 48 high caries- risk children (DMFS >8), aged 6- 7 years with newly erupted permanent first molars (initial lesion with 13 < LF value<30). A total of 140 teeth were divided randomly into four groups (n= 35): G1.Duraphat Varnish containing 5% NaF, G2. Clinpro (TM) White Varnish containing 5% NaF with TCP, G3.Embrace (TM) Varnish containing 5% NaF with CXP, G4. MI Varnish containing 5% NaF with CPP-ACP. All dental treatments of the patients were com-pleted before the varnish application. The varnishes were applied to the targeted teeth at baseline, 1 and 3 months. Patients were called for follow-up appointments at 1, 3 and 6 months, and LF scanning was used to monitor mineralization changes. Data were analysed statistically by Wilcoxon signed- rank and Mann-Whitney U- t e s t s .Results: In total, 40 children (122 teeth) completed the trial. At the end of 6 months, the amount of reduction in LF values (indicating remineralization) are as follows: NaF with CXP(6.87 +/- 4.32) < NaF with TCP(7.36 +/- 7.05) < NaF(7.40 +/- 7.03) < NaF with CPP- ACP(8.33 +/- 4.90). All of the varnishes resulted in significant decrease in LF measure-ments and there was no significant difference between control (NaF alone) group and other groups. Only MI varnish had a significantly greater remineralization effect than Embrace (TM) Varnish (p < 0.05).Conclusion: As a non-invasive approach, CPP-ACP, TCP and CXP containing NaF var-nishes have the potential to remineralize initial caries lesions on permanent first mo-lars in high caries- risk children
dc.description.sponsorshipThe authors received no financial support and declare. Clinical Trials registration number: NCT04124887.
dc.description.sponsorshipThe authors received no financial support and declare. Clinical Trials registration number: NCT04124887.
dc.identifier.doi10.1111/idh.12778
dc.identifier.endpage710
dc.identifier.issn1601-5029
dc.identifier.issn1601-5037
dc.identifier.issue3
dc.identifier.pmid37831601
dc.identifier.scopus2-s2.0-85174020361
dc.identifier.scopusqualityQ1
dc.identifier.startpage703
dc.identifier.urihttps://doi.org/10.1111/idh.12778
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25389
dc.identifier.volume22
dc.identifier.wosWOS:001085495100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Dental Hygiene
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectantimicrobial agents; antiplaque agents; conservative; fluoride varnishes
dc.titleRemineralization effect of NaF, NaF with TCP, NaF with CPP-ACP and NaF with CXP varnishes on newly erupted first permanent molars: A randomized controlled trial
dc.typeArticle

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