The screening of the safety profile of polymeric based amoxicillin nanoparticles in various test systems

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dc.authoridANLAS, CEREN/0000-0002-7997-016X
dc.authoridcharehsaz, mohammad/0000-0002-4545-0756
dc.authoridAydin, Ahmet/0000-0003-3499-6435
dc.authoridUSTUN ALKAN, Fulya/0000-0003-1782-9467
dc.contributor.authorGuncum, Enes
dc.contributor.authorBakirel, Tulay
dc.contributor.authorAnlas, Ceren
dc.contributor.authorIsiklan, Nuran
dc.contributor.authorAlkan, Fulya Ustun
dc.contributor.authorCharehsaz, Mohammad
dc.contributor.authorAydin, Ahmet
dc.date.accessioned2025-01-21T16:55:20Z
dc.date.available2025-01-21T16:55:20Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractNanotechnology-based drugs show superiority over conventional medicines because of increased bioavailability, lower accumulation in non-target tissues, and improved therapeutic index with increased accumulation at target sites. However, it is important to be aware of possible problems related to the toxicity of these products, which have therapeutically superior properties. Accordingly, the present study was designed to investigate the safety profile of amoxicillin nanoparticles (AmxNPs) that we developed to increase the oral bioavailability of amoxicillin (Amx) in poultry. In the first part of the study, the genotoxicity potential of AmxNPs was evaluated using the Ames test and the in vitro comet assay. The results of Ames test showed that none of the tested concentrations of Amx and AmxNPs cause a significant increase in the revertant number of Salmonella typhimurium strains TA98, and TA100, either with or without metabolic activation. Similarly, the comet assay revealed that AmxNPs did not induce DNA damage at any of the concentrations used, whereas high-dose (200 mu g/mL) of Amx caused a significant increase in the percentage of DNA in the tail. In the second part of the study, the toxicity potential of AmxNPs on broilers was investigated by measuring biochemical parameters. In vivo results demonstrated that AmxNps did not cause a significant change in biochemical parameters, whereas Amx increased ALT, glucose, and cholesterol levels at certain sampling times. The obtained findings suggest that AmxNPs could be a safe promising potential drug in drug delivery systems. (C) 2021 Elsevier B.V. All rights reserved.
dc.description.sponsorshipDepartment of Scientific Research Projects, Istanbul UniversityCerrahpasa, TURKEY [44188, 59162]
dc.description.sponsorshipThis study was supported by Department of Scientific Research Projects, Istanbul UniversityCerrahpasa, TURKEY [Project Number: 44188 and Project Number 59162] .
dc.identifier.doi10.1016/j.toxlet.2021.05.001
dc.identifier.endpage9
dc.identifier.issn0378-4274
dc.identifier.issn1879-3169
dc.identifier.pmid33984417
dc.identifier.scopus2-s2.0-85106380241
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.toxlet.2021.05.001
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25760
dc.identifier.volume348
dc.identifier.wosWOS:000663831300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofToxicology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAmoxicillin; Amoxicillin nanoparticles; Genotoxicity; Poultry; Blood biochemical parameters
dc.titleThe screening of the safety profile of polymeric based amoxicillin nanoparticles in various test systems
dc.typeArticle

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