Can Resistin be a New Indicator of Neonatal Sepsis?

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dc.contributor.authorAliefendioglu, Didem
dc.contributor.authorGursoy, Tugba
dc.contributor.authorCaglayan, Osman
dc.contributor.authorAktas, Alev
dc.contributor.authorOvali, Fahri
dc.date.accessioned2020-06-25T18:07:51Z
dc.date.available2020-06-25T18:07:51Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Sepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine might play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. There are no data in the literature on resistin levels of premature newborns with sepsis, which can also cause inflammatory response. The objective of this study was to evaluate whether resistin can be used as an indicator in neonatal sepsis of preterm babies. Materials and methods: Forty-three premature newborns considered to have sepsis were included in the study. Forty-three gestational and postnatal age- and sex-matched premature newborns without premature prolonged rupture of membrane or sepsis served as controls. Results: The median resistin and interleukin-6 (IL-6) levels of the premature babies with sepsis were 85.9 ng/mL and 342.7 pg/mL, respectively, and were higher than those of the control group (29.9 ng/mL and 17.7 pg/mL, respectively). The sensitivity, specificity, positive, and negative predictive values for resistin were 73.7%, 45.8%, 68.3%, and 52.4%, respectively. Conclusion: Resistin levels were higher in premature newborns with sepsis and correlated with IL-6 levels, which is an indicator of neonatal sepsis. This suggests that resistin may also be used in the diagnosis of neonatal sepsis. However, it has limited value when compared with the other inflammatory markers including C-reactive protein, procalcitonin, and IL-6. Copyright (C) 2013, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.description.sponsorshipMother and Child Health Foundation, Istanbul, Turkeyen_US
dc.description.sponsorshipThis study was supported by the Mother and Child Health Foundation, Istanbul, Turkey.en_US
dc.identifier.citationAliefendioglu, D., Gürsoy, T., Çağlayan, O., Aktaş, A., & Ovalı, F. (2014). Can resistin be a new indicator of neonatal sepsis?. Pediatrics and neonatology, 55(1), 53–57.en_US
dc.identifier.doi10.1016/j.pedneo.2013.04.012
dc.identifier.endpage57en_US
dc.identifier.issn1875-9572
dc.identifier.issue1en_US
dc.identifier.pmid23820264
dc.identifier.scopus2-s2.0-84893822815
dc.identifier.scopusqualityQ2
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1016/j.pedneo.2013.04.012
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5677
dc.identifier.volume55en_US
dc.identifier.wosWOS:000332353600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofPediatrics And Neonatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC-reactive proteinen_US
dc.subjectinterleukin-6en_US
dc.subjectprematureen_US
dc.subjectprocalcitoninen_US
dc.subjectresistinen_US
dc.subjectsepsisen_US
dc.titleCan Resistin be a New Indicator of Neonatal Sepsis?en_US
dc.typeArticle

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