Effect of Local and Systemic Dimethylsulfoxide on Peripheral Nerve Repair: A Controlled Randomized Experimental Study

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dc.contributor.authorSanli, Elif
dc.contributor.authorDincel, Gungor Cagdas
dc.contributor.authorUmay, Ebru
dc.date.accessioned2020-06-25T18:34:00Z
dc.date.available2020-06-25T18:34:00Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionDINCEL, Gungor Cagdas/0000-0002-6985-3197
dc.description.abstractIntroduction: We investigated the possible beneficial effect of dimethylsulfoxide (DMSO) on peripheral nerve repair in rats. Methods: Seventy rats were divided into four groups: control, sham, DMSO-L, and DMSO-IP. Except in the control group, nerve repair was done at the right sciatic nerve. DMSO was administered locally and intraperitoneally for 12 weeks to the DMSO-L and DMSO-IP groups, respectively. No therapeutic agent was administered to the other groups. Nerve regeneration was assessed by behavioral, electrophysiological, histopathological, and immunohistochemical tests. Results: With the exception of S-100 protein expression, all results indicate that DMSO has a beneficial effect on peripheral nerve regeneration. Functional nerve recovery was notably more evident in the DMSO-L than in the DMSO-IP group. Under macroscopic examination, nerve scores of the regeneration area in the DMSO-L group was also better than in the others. Discussion: We believe that DMSO can improve peripheral nerve regeneration in rats.en_US
dc.description.sponsorshipScientific Research Project Fund of our universityen_US
dc.description.sponsorshipThe study was funded by the Scientific Research Project Fund of our university.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/08941939.2019.1644403
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.pmid31343376
dc.identifier.scopus2-s2.0-85102484742
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/08941939.2019.1644403
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7733
dc.identifier.wosWOS:000479623100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdimethylsulfoxideen_US
dc.subjectDMSOen_US
dc.subjectperipheral nerve injuryen_US
dc.subjectneurotmesisen_US
dc.subjectnerveen_US
dc.subjectmuscleen_US
dc.titleEffect of Local and Systemic Dimethylsulfoxide on Peripheral Nerve Repair: A Controlled Randomized Experimental Studyen_US
dc.typeArticle

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