Comparison of Effects of Dexmedetomidine-ketamine and Dexmedetomidine-midazolam Combinations in Transurethral Procedures

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dc.contributor.authorKöse, Emine Arzu
dc.contributor.authorHonca, Mehtap
dc.contributor.authorYılmaz, Erdal
dc.contributor.authorBatislam, Ertan
dc.contributor.authorApan, Alpaslan
dc.date.accessioned2020-06-25T18:06:34Z
dc.date.available2020-06-25T18:06:34Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractOBJECTIVE To compare the effects of dexmedetomidine-ketamine and dexmedetomidine-midazolam combinations on the recovery time, hemodynamic and respiratory variables, and side effects in patients undergoing transurethral procedures. METHODS Sixty patients scheduled for elective outpatient transurethral procedure were randomized into 2 groups. In the group K, a ketamine-dexmedetomidine combination was administered, and in the group M, midazolam-dexmedetomidine was administered, to provide sedation/analgesia. Pain and sedation levels were assessed using visual analog score (VAS) and Ramsey Sedation Scale, respectively. The recovery time was assessed with the scale of Aldrete. Time was measured and recorded to the moment at which patient responses brought the Aldrete score to 10 points. Time to eye opening and length of stay in the recovery room were recorded. RESULTS Group M showed significantly lower mean arterial pressure (MAP) values at 5 and 10 minutes during the procedure when compared with group K (P = .02 and P = .01, respectively). Visual analogue scale scores were greater in group M than in group K at 5 and 10 minutes for the transurethral procedure (P = .039 and P = .028, respectively). Sedation scores were similar between groups during the procedure. Time to eye opening and length of recovery room stay were shorter (P < .001 and P < .001, respectively), and Aldrete scores were greater in group K than group M. CONCLUSION Both combinations provided satisfactory sedation levels, but the dexmedetomidine-ketamine combination provided better analgesia and hemodynamic stability, with less nausea and vomiting and shorter recovery time, than the dexmedetomidine-midazolam combination. UROLOGY 79: 1214-1219, 2012. (c) 2012 Elsevier Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.urology.2012.02.040
dc.identifier.endpage1219en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue6en_US
dc.identifier.pmid22656405
dc.identifier.scopus2-s2.0-84861740191
dc.identifier.scopusqualityQ2
dc.identifier.startpage1214en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2012.02.040
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5258
dc.identifier.volume79en_US
dc.identifier.wosWOS:000304720600012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComparison of Effects of Dexmedetomidine-ketamine and Dexmedetomidine-midazolam Combinations in Transurethral Proceduresen_US
dc.typeArticle

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