Comparison of growth factor levels in patients with normal and hypospadiac prepuce
Yükleniyor...
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technical Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To compare the growth factor levels in patients with normal and hypospadiac prepuce. Materials and methods: Patients who underwent hypospadias repair were included in the study. The prepuce was excised after achieving successful hypospadias repair with satisfactory functional and cosmetic appearance. The patients who underwent preputial reconstructions and complicated repairs were excluded. The control group consists of boys without hypospadias. Elective circumcision was performed to have normal preputial samples. The VEGF levels, VEGF receptor (VEGFR) and TGF-beta receptor (TGF-beta-R) expressions were evaluated in preputial tissues by immunohistochemical analysis. Results: Fifteen patients were included in each group. The mean age of patients with normal and hypospadiac prepuce was 4.33 +/- 1.39 and 4.07 +/- 1.58, respectively (P>0.05). Although VEGF, VEGFR, and TGF-beta-R levels were decreased in hypospadiac prepuce, statistical significance was detected only in VEGF levels (P<0.05, Mann-Whitney U test). Conclusion: The decreased levels of VEGF obtained from patients with hypospadiac prepuce suggest a structural anomaly related with angiogenesis. This structural difference can be considered one of the factors causing impaired wound healing and recurrent complications after preputial reconstructions in hypospadias repair.
Açıklama
Joint Congress of British-Association-of-Pediatric-Surgeons/European-Pediatric-Surgery-Association -- JUN 17-20, 2009 -- Graz, AUSTRIA
Soyer, Tutku/0000-0003-1505-6042
Soyer, Tutku/0000-0003-1505-6042
Anahtar Kelimeler
Hypospadias, prepuce, vascular endothelial growth factor, transforming growth factor beta
Kaynak
Turkish Journal Of Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
41
Sayı
1
Künye
Soyer, T., Ayva, E. Ş., Atasoy, P., Aslan, M. K., Çakmak, A. M. (2011). Comparison of growth factor levels in patients with normal and hypospadiac prepuce. Turkish Journal of Medical Sciences, 41(1), 81 - 85.
