Comparison of growth factor levels in patients with normal and hypospadiac prepuce

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dc.contributor.authorSoyer, Tutku
dc.contributor.authorAyva, Ebru Sebnem
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorAslan, Mustafa Kemal
dc.contributor.authorCakmak, Ahmet Murat
dc.date.accessioned2020-06-25T17:52:02Z
dc.date.available2020-06-25T17:52:02Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionJoint Congress of British-Association-of-Pediatric-Surgeons/European-Pediatric-Surgery-Association -- JUN 17-20, 2009 -- Graz, AUSTRIA
dc.descriptionSoyer, Tutku/0000-0003-1505-6042
dc.description.abstractAim: To compare the growth factor levels in patients with normal and hypospadiac prepuce. Materials and methods: Patients who underwent hypospadias repair were included in the study. The prepuce was excised after achieving successful hypospadias repair with satisfactory functional and cosmetic appearance. The patients who underwent preputial reconstructions and complicated repairs were excluded. The control group consists of boys without hypospadias. Elective circumcision was performed to have normal preputial samples. The VEGF levels, VEGF receptor (VEGFR) and TGF-beta receptor (TGF-beta-R) expressions were evaluated in preputial tissues by immunohistochemical analysis. Results: Fifteen patients were included in each group. The mean age of patients with normal and hypospadiac prepuce was 4.33 +/- 1.39 and 4.07 +/- 1.58, respectively (P>0.05). Although VEGF, VEGFR, and TGF-beta-R levels were decreased in hypospadiac prepuce, statistical significance was detected only in VEGF levels (P<0.05, Mann-Whitney U test). Conclusion: The decreased levels of VEGF obtained from patients with hypospadiac prepuce suggest a structural anomaly related with angiogenesis. This structural difference can be considered one of the factors causing impaired wound healing and recurrent complications after preputial reconstructions in hypospadias repair.en_US
dc.description.sponsorshipBritish Assoc Pediatr Surg, European Pediatr Surg Assocen_US
dc.identifier.citationSoyer, T., Ayva, E. Ş., Atasoy, P., Aslan, M. K., Çakmak, A. M. (2011). Comparison of growth factor levels in patients with normal and hypospadiac prepuce. Turkish Journal of Medical Sciences, 41(1), 81 - 85.en_US
dc.identifier.doi10.3906/sag-1003-718
dc.identifier.endpage85en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-83155180721
dc.identifier.scopusqualityQ1
dc.identifier.startpage81en_US
dc.identifier.trdizinid111826
dc.identifier.urihttps://doi.org/10.3906/sag-1003-718
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5063
dc.identifier.volume41en_US
dc.identifier.wosWOS:000288413100011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypospadiasen_US
dc.subjectprepuceen_US
dc.subjectvascular endothelial growth factoren_US
dc.subjecttransforming growth factor betaen_US
dc.titleComparison of growth factor levels in patients with normal and hypospadiac prepuceen_US
dc.typeArticle

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