The expression of GST isoenzymes and p53 in non-small cell lung cancer

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dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorAydin, Mehtap
dc.contributor.authorDemirag, Funda
dc.contributor.authorYazici, Ulku
dc.contributor.authorOzhavzali, Muzeyyen
dc.contributor.authorKilic, Murat
dc.contributor.authorIscan, Mesude
dc.date.accessioned2020-06-25T17:51:22Z
dc.date.available2020-06-25T17:51:22Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionKilic, Murat/0000-0002-1377-2021; Demirag, Funda/0000-0003-4790-8369
dc.description.abstractThis study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alpha, theta and p53 was assessed by immunohistochemistry for primary lung carcinomas of 50 patients from the Sanitarium Education and Research Hospital, Ankara lung cancer collection. The relationships between expression of the glutathione-S-transferase isoenzymes, p53 in normal and tumor tissue by Student T test and the clinicopathological data were also examined by Spearman Rank tests. When the normal and tumor tissue of these cases were compared according to their staining intensity and percentage of positive staining, glutathione-S-transferase alpha, pi, mu, theta expressions in tumor cells was significantly higher than normal cells (p<0.05). There was no significant difference in the expression of p53 between normal and tumor cells (p>0.05). When the immunohistochemical results of glutathione-S-transferase isoenzymes and p53 were correlated with the clinical parameters, there were no significant associations between glutathione-S-transferases and p53 expressions and tumor stage, tumor grade and smoking status (p>0.05).en_US
dc.identifier.citationOguztüzun, S., Aydin, M., Demirag, F., Yazici, U., Ozhavzali, M., Kiliç, M., & Işcan, M. (2010). The expression of GST isoenzymes and p53 in non-small cell lung cancer. Folia histochemica et cytobiologica, 48(1), 122–127.en_US
dc.identifier.doi10.2478/v10042-008-0084-6
dc.identifier.endpage127en_US
dc.identifier.issn0239-8508
dc.identifier.issn1897-5631
dc.identifier.issue1en_US
dc.identifier.pmid20529827
dc.identifier.scopus2-s2.0-77954416196
dc.identifier.scopusqualityQ2
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.2478/v10042-008-0084-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4832
dc.identifier.volume48en_US
dc.identifier.wosWOS:000282022700019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Histochemica Et Cytobiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlung canceren_US
dc.subjectglutathione-S-transferaseen_US
dc.subjectp53en_US
dc.subjectimmunohistochemistryen_US
dc.titleThe expression of GST isoenzymes and p53 in non-small cell lung canceren_US
dc.typeArticle

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