The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci
Yükleniyor...
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Patojen bakteri suşlarında slime oluşturma oranı daha yüksek bulunmuştur. Slime oluşumunu artıran faktörler enfeksiyon riskini artırırken azaltanlar ise bu riski düşürmektedir. Çalışmamızda Yoğun Bakım Ünitelerinde kateter aracılığı infüzyon şeklinde uygulanan bazı ilaçların koagülaz negatif Stafilokok’larda slime oluşumuna etkisi araştırıldı. Gereç ve yöntem: Glyceryl trinitrate (Perlinganit), Dexmedetomidine (Precedex), Esmolol (Brevibloc) ve Propofol (Propofol)’un slime oluşumuna etkileri 24’ü kan kültürlerinden izole edil ve biri American Type Culture Collection (ATCC) 12228 kodlu referans Staphylococcus epidermidis suşu üzerinde araştırıldı. Slime oluşumu Christensen tarafından tarif edilmiş olan “Kantitatif mikrodilüsyon plak testi” yöntemi ile belirlendi. Bulgular: Kontrol kuyucuklarında 8 bakteri slime oluşturdu. Esmolol içeren besi yerinde 5, Glyceryl trinitrate’lı besiyerinde 21, dexmedetomidine olan besiyerinde 15, propofol’lü besiyerinde 18 bakteri slime pozitif bulundu. Glyceryl trinitrate, dexmedetomidine ve propofolün slime pozitifliğini kontrole göre anlamlı ölçüde arttırdığı saptandı. Sonuç: Bu çalışmanın sonuçlarının ışığında; ilaç ve/ veya katkı maddelerinin slime üretimine etkili olabileceği sonucuna varıldı. Kateter yoluyla uygulanan preparatların etkileri araştırılmalı ve kullanımları sırasında bu etkilerinin olabileceği akılda tutulmalıdır.
Objectives: Higher rate of slime production has been found in pathogen bacteria strains. Accordingly, the factors that contribute to higher slime production rate increase the infection risk, while the factors that reduce the slime production rate will reduce the infection risk. The effect of some drugs that are administered through catheters in intensive care units on slime production with coagulase negative Staphylococci was investigated. Materials and methods: In this study, the effect of four different preparations containing Glyceryl trinitrate (Perlinganit ®), Dexmedetomidine (Precedex®), Esmolol (Brevibloc®), and Propofol (Propofol®) on slime production of 24 Staphylococcus epidermidis strains isolated from blood cultures of patients, and reference strain were investigated. Slime production was determined using ‘the quantitative microdilution plaque test‘ described by Christensen. Results: Under controlled medium, eight strains formed slimes, and in the media containing esmolol, glyceryl trinitrate, dexmedetomidine, and propofol slimes were positive for five, 21, 15, and 18 strains, respectively. The rate of slime production in glyceryl trinitrate, dexmedetomidine, and propofol containing media were higher than that of the controls. Conclusions: In the light of the results of this study, it is concluded that the drugs and/or additives increase the rate of slime production. The effects of the preparations administered through catheters on slime production should be investigated, and these effects should be kept in mind during their use.
Objectives: Higher rate of slime production has been found in pathogen bacteria strains. Accordingly, the factors that contribute to higher slime production rate increase the infection risk, while the factors that reduce the slime production rate will reduce the infection risk. The effect of some drugs that are administered through catheters in intensive care units on slime production with coagulase negative Staphylococci was investigated. Materials and methods: In this study, the effect of four different preparations containing Glyceryl trinitrate (Perlinganit ®), Dexmedetomidine (Precedex®), Esmolol (Brevibloc®), and Propofol (Propofol®) on slime production of 24 Staphylococcus epidermidis strains isolated from blood cultures of patients, and reference strain were investigated. Slime production was determined using ‘the quantitative microdilution plaque test‘ described by Christensen. Results: Under controlled medium, eight strains formed slimes, and in the media containing esmolol, glyceryl trinitrate, dexmedetomidine, and propofol slimes were positive for five, 21, 15, and 18 strains, respectively. The rate of slime production in glyceryl trinitrate, dexmedetomidine, and propofol containing media were higher than that of the controls. Conclusions: In the light of the results of this study, it is concluded that the drugs and/or additives increase the rate of slime production. The effects of the preparations administered through catheters on slime production should be investigated, and these effects should be kept in mind during their use.
Açıklama
Anahtar Kelimeler
Enfeksiyon Hastalıkları, Mikrobiyoloji
Kaynak
Journal of Microbiology and Infectious Diseases
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
4
Künye
Göçmen, J. S., Büyükkoçak, Ü., Azap, A., Pekuz, Y. Ö., Çağlayan, O. (2012). The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. Journal of Microbiology and Infectious Diseases, 2(4), 150 - 154.
