Bronchial hyperresponsiveness in patients with obstructive sleep apnea syndrome

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dc.contributor.authorBulcun E.
dc.contributor.authorEkici M.
dc.contributor.authorEkici A.
dc.contributor.authorTireli G.
dc.contributor.authorKarakoç T.
dc.contributor.authorŞentürk E.
dc.contributor.authorAltinkaya V.
dc.date.accessioned2020-06-25T15:17:22Z
dc.date.available2020-06-25T15:17:22Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: The relationship between obstructive sleep apnea syndrome (OSAS) and bronchial hyperresponsiveness (BHR) is not well known. In this study, we investigated the association between BHR and disease severity in patients with OSAS. Materials and Methods: Fourty seven (37 male/10 female) OSAS patients admitted with polysomnography enrolled to the study. Histamine bronchial challenge test was performed and body mass index (BMI, kg/m2) was calculated. Presence of BHR was diagnosed as positivity of bronchial provocative test (BPT) (PD values ? 16 mg/mL). Patients were questioned with Epworth sleepiness scale (ESS). Results: Histamine bronchial challenge test was positive in 21 of 47 patients. There were significant negative correlations between PD 20 value and AHI (r= -0.47, p= 0.03), BMI (r= -0.45, p= 0.03), and ESS score (r= -0.45, p= 0.03) in the patients with BHR. In addition, AHI (p= 0.03), BMI (p= 0.02), ESS scores (p= 0.03) were higher in patients with BHR (21 patients) than in patients not having BHR (26 patients). Significant negative relation was found between PD 20 value and AHI (?=-0.45, p= 0.03) and significant positive relation was found between presence of BHR and AHI (p= 0.04), BMI (p= 0.03) independently of age and sex in multiple regression analysis. Conclusion: BHR is common in patients with OSAS. As severity of OSAS increased, severity of BHR increased. In addition, obesity may trigger presence of BHR in patients with OSAS.en_US
dc.identifier.citationBulgun, E., Ekici, M. S., Ekici, A., Tireli, G., Karakoç, T., Şentürk, E., Altınkaya, V. (2013). Bronchial hyperresponsiveness in patients with obstructive sleep apnea syndrome. Tüberküloz ve Toraks, 61(3), 221 - 226.en_US
dc.identifier.doi10.5578/tt.5791
dc.identifier.endpage226en_US
dc.identifier.issn04941373
dc.identifier.issue3en_US
dc.identifier.pmid24298964
dc.identifier.scopus2-s2.0-84888811026
dc.identifier.scopusqualityQ3
dc.identifier.startpage221en_US
dc.identifier.trdizinid154830
dc.identifier.urihttps://doi.org/10.5578/tt.5791
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2326
dc.identifier.volume61en_US
dc.identifier.wosWOS:000421333900007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAnkara Universityen_US
dc.relation.ispartofTuberkuloz ve Toraks
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBronchial hyperresponsivenessen_US
dc.subjectObesityen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.titleBronchial hyperresponsiveness in patients with obstructive sleep apnea syndromeen_US
dc.title.alternativeObstrüktif uyku apne sendromu tanılı hastalarda bronş hiperreaktivitesien_US
dc.typeArticle

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