Topical application of olive oil macerate of Momordica charantia L. promotes healing of excisional and incisional wounds in rat buccal mucosa

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dc.contributor.authorİlhan, Mert
dc.contributor.authorBolat, İsmail Eser
dc.contributor.authorSuntar, İpek
dc.contributor.authorKoklu, Harika Kutluay
dc.contributor.authorCankal, Dilek A. Ugar
dc.contributor.authorKeleş, Hikmet
dc.contributor.authorAkkol, Esra Küpeli
dc.date.accessioned2020-06-25T18:12:38Z
dc.date.available2020-06-25T18:12:38Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionSUNTAR, IPEK/0000-0003-4201-1325; keles, hikmet/0000-0002-2308-0811; Kupeli Akkol, Esra/0000-0002-5829-7869; ilhan, mert/0000-0001-5042-3915; Bolat, Ismail Eser/0000-0003-3128-0466
dc.description.abstractObjective: In Turkish folk medicine Momordica charantia L. is used for wound healing. The aim of the present study is to investigate this folkloric knowledge and confirm the plant's potential effect on buccal mucosa wound in the rat. Design: Wound healing activity of olive oil macerate of Momordica charantia L was investigated in linear incision and circular excision wound models created in the buccal mucosa of the rat. The tissues were histopathologically evaluated, moreover, hydroxyproline contents of the tissues were determined. The anti-inflammatory activity was also assessed by using Whittle method with some modifications. Results: Olive oil macerate of M. charantia showed significant wound healing activity both in incision (45.1%) and excision (89.8%) wound models and demonstrated anti-inflammatory activity with the inhibition value of 31.3% at the dose of 100 mg/kg. Conclusion: The experimental data revealed that M. charantia showed significant wound healing and anti-inflammatory effect. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.archoralbio.2015.09.006
dc.identifier.endpage1713en_US
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.issue12en_US
dc.identifier.pmid26431827
dc.identifier.scopus2-s2.0-84942938028
dc.identifier.scopusqualityQ1
dc.identifier.startpage1708en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2015.09.006
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5993
dc.identifier.volume60en_US
dc.identifier.wosWOS:000365065800002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives Of Oral Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectCucurbitaceaeen_US
dc.subjectExcisionen_US
dc.subjectIncisionen_US
dc.subjectMomordica charantiaen_US
dc.subjectTensiometeren_US
dc.subjectWound healingen_US
dc.titleTopical application of olive oil macerate of Momordica charantia L. promotes healing of excisional and incisional wounds in rat buccal mucosaen_US
dc.typeArticle

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