Alteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapy

Basit Öğe Kaydı
dc.contributor.authorUzunçakmak, Tuğba Kevser
dc.contributor.authorKaradağ, Ayşe Serap
dc.contributor.authorÖzkanlı, Şeyma
dc.contributor.authorAkbulak, Özge
dc.contributor.authorÖzlü, Emin
dc.contributor.authorAkdeniz, Necmettin
dc.contributor.authorOğuztüzün, Serpil
dc.date.accessioned2020-06-25T18:35:10Z
dc.date.available2020-06-25T18:35:10Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.descriptionUzuncakmak, Tugba Kevser Ustunbas/0000-0001-8057-3463
dc.description.abstractWe compared the expression profiles of antimicrobial peptides (AMPs) in psoriatic skin before and after narrow band ultraviolet B (nb-UVB) phototherapy and compared the levels to healthy controls. We studied 15 male and 12 female patients with psoriasis vulgaris, and 11 female and nine male control individuals. The patient group was treated with 24-36 sessions of nb-UVB phototherapy. Immunohistochemical staining for human beta defensin 1 (hBD-1) and human beta defensin 2 (hBD-2) expression of lesioned and control skin was performed prior to and following phototherapy. After phototherapy, the psoriatic area and severity index (PASI) decreased significantly in the treated patients compared to controls. The hBD-1 level was significantly higher in psoriasis patients than healthy controls. We found no statistically significant difference in hBD-1 and hBD 2 levels before and after phototherapy in the patient group. Although hBD-1 plays a role in psoriasis, levels of human beta defensin 1 and 2 are not affected significantly by phototherapy.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/10520295.2019.1673901
dc.identifier.endpage248en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid31650859
dc.identifier.scopus2-s2.0-85074471747
dc.identifier.scopusqualityQ2
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1673901
dc.identifier.urihttps://hdl.handle.net/20.500.12587/8137
dc.identifier.volume95en_US
dc.identifier.wosWOS:000492502600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobial peptidesen_US
dc.subjectbeta defensin-1en_US
dc.subjectbeta defensin-2en_US
dc.subjecthumanen_US
dc.subjectphototherapyen_US
dc.subjectpsoriasisen_US
dc.titleAlteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapyen_US
dc.typeArticle

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