Distribution of 3β-Hydroxysteroid Dehydrogenase in the Cerebellum in Canine Distemper Virus Infection

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dc.contributor.authorYarim, M.
dc.contributor.authorKabakci, N.
dc.date.accessioned2020-06-25T17:34:58Z
dc.date.available2020-06-25T17:34:58Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description/0000-0002-0636-4214
dc.description.abstractThe cerebella of eight dogs naturally infected with canine distemper virus (CDV) and two normal dogs were examined immunohistochemically for glial fibrillary acidic protein (GFAP) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD). The clinical diagnosis of canine distemper was Confirmed histopathologically and by the immunohistochemical demonstration of CDV antigen. In all dogs (healthy and infected), the Purkinje cells of the cerebellum were immunolabelled for 3beta-HSD activity. In infected dogs, 3beta-HSD labelling was prominent in astrocytes (particularly in areas of astrocytosis) whereas in healthy dogs such immunolabelling was weak. Double immunolabelling demonstrated that all GFAP-positive cells (especially in demyelinating areas) were also positive for 3beta-HSD. The results suggest that 3beta-HSD expression by astrocytes is associated with demyelination in CDV infection. (C) 2002 Elsevier Science Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1053/jcpa.2002.0594
dc.identifier.endpage296en_US
dc.identifier.issn0021-9975
dc.identifier.issue4en_US
dc.identifier.pmid12443737
dc.identifier.scopus2-s2.0-0036852588
dc.identifier.scopusqualityQ2
dc.identifier.startpage290en_US
dc.identifier.urihttps://doi.org/10.1053/jcpa.2002.0594
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2968
dc.identifier.volume127en_US
dc.identifier.wosWOS:000179500000008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Ltd Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Comparative Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDistribution of 3β-Hydroxysteroid Dehydrogenase in the Cerebellum in Canine Distemper Virus Infectionen_US
dc.typeArticle

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