Role of Platelet to Lymphocyte Ratio as a Biomedical Marker for the Pre-Operative Diagnosis of Acute Appendicitis

Basit Öğe Kaydı
dc.contributor.authorPehlivanli, Faruk
dc.contributor.authorAydin, Oktay
dc.date.accessioned2020-06-25T18:30:23Z
dc.date.available2020-06-25T18:30:23Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionAydin, Oktay/0000-0001-5728-0128
dc.description.abstractBackground: Recently, the possible use of laboratory parameters such as full blood count, neutrophil count, neutrophil to lymphocyte ratio (NLR), thrombocyte count (PLT), and mean thrombocyte volume (MPV) have been investigated in diagnosis of acute appendicitis and the prediction of complications. The aim of this study was to investigate the utility of the platelet to lymphocyte ratio (PLR) value as a biomedical marker in the prediction of acute appendicitis and perforated appendix. Patients and Methods: The data were retrieved from the hospital records related to age, gender, length of stay in hospital, MPV, leukocyte, neutrophil, lymphocyte, and thrombocyte counts measured in the peripheral venous blood sample on presentation, NLR and PLR values, and the pathology results. The patients were grouped according to the pathology results as follows: group 1 (normal appendix, n = 86); group 2 (acute appendicitis, n = 458); group 3 (perforated appendicitis, n = 14). Results: The study included a total of 558 patients (308 males; 250 females) with a mean age of 34.24 +/- 14.27 years. The mean length of stay in hospital was 2.12 days. The leukocyte and neutrophil count values of group 1 were lower than group 2 and group 3 values (p < 0.001). The lymphocyte count values of group 1 were higher than those of the other groups (p < 0.001). The NLR and PLR values of group 1 were lower than group 2 and group 3 values (p < 0.001). The length of stay in hospital was shorter in group 1 than in group 2 and group 3 (p = 0.42). The receiver operating characteristic (ROC) curve test results showed that PLR and NLR values were sensitive and specific to differentiate normal appendix, acute appendicitis, and perforated appendicitis. Conclusion: The results of this study demonstrated that PLR value, such as NLR, could be evaluated as a new biomarker that could be valuable in the differentiation of normal appendix from acute appendicitis and in the differentiation of acute appendicitis from perforated appendicitis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1089/sur.2019.042
dc.identifier.endpage636en_US
dc.identifier.issn1096-2964
dc.identifier.issn1557-8674
dc.identifier.issue8en_US
dc.identifier.pmid31120412
dc.identifier.scopus2-s2.0-85074939137
dc.identifier.scopusqualityQ2
dc.identifier.startpage631en_US
dc.identifier.urihttps://doi.org/10.1089/sur.2019.042
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7628
dc.identifier.volume20en_US
dc.identifier.wosWOS:000496634600007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofSurgical Infections
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute appendicitisen_US
dc.subjectbiomarkeren_US
dc.subjectperforated appendicitisen_US
dc.subjectneutrophil to lymphocyte ratioen_US
dc.subjectplatelet to lymphocyte ratioen_US
dc.titleRole of Platelet to Lymphocyte Ratio as a Biomedical Marker for the Pre-Operative Diagnosis of Acute Appendicitisen_US
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu