Assessment of erythrocyte morphology in patients with type 2 diabetes mellitus: a pilot study of electron microscopy-based analysis in relation to healthy controls

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dc.authoridSavranlar, Yasemin/0000-0003-2221-4643
dc.authoridMortas, Tulay/0000-0003-3635-9923
dc.contributor.authorMortas, Tulay
dc.contributor.authorDurmaz, Senay Arikan
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorSavranlar, Yasemin
dc.date.accessioned2025-01-21T16:34:26Z
dc.date.available2025-01-21T16:34:26Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: The present study aimed to assess erythrocyte morphology in newly diagnosed type 2 diabetes mellitus patients using scanning electron microscopy. Materials and methods: In total, 30 patients admitted to endocrine outpatient clinics were included in the study. The patients were divided into two groups according to their fasting blood glucose levels: type 2 diabetes mellitus (n = 15, fasting blood glucose levels >= 126 mg/dL) and control (n = 15, fasting blood glucose levels < 99 mg/dL). The patient's demographic characteristics, haemoglobin A1c levels, and scanning electron microscopy findings regarding erythrocyte morphology were recorded. Results: There was no significant difference between the control and type 2 diabetes mellitus group in terms of the participants' age (51.13 +/- 8.53 vs. 50.33 +/- 8.72 years, p = 0.8) and the male/female ratio (9/6 vs. 9/6). In the control group, discocytes were abundant, echinocytes were rare, and spherocytes were absent. On the other hand, discocytes were less common and echinocyte-shaped erythrocytes were more common in the type 2 diabetes mellitus group than in the control group. In addition, spherocytes were detected in the type 2 diabetes mellitus group. Moreover, the diameter of discocytes was significantly lower (p = 0.014), and blood glucose and haemoglobin A1c levels were significantly higher (p < 0.05 for both) in the type 2 diabetes mellitus group than in the control group. Conclusion: Our findings indicate that high glucose levels in type 2 diabetes mellitus patients lead to significant alterations in erythrocyte morphology, including decreased erythrocyte deformability and the formation of echinocytes and spherocytes due to eryptosis. The possibility of decreased erythrocyte deformability due to excessive eryptosis may disturb microcirculation in newly diagnosed, treatment-naive type 2 diabetes mellitus patients who do not have any complications.
dc.identifier.doi10.3906/sag-2103-336
dc.identifier.endpage2542
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5
dc.identifier.pmid34174794
dc.identifier.scopus2-s2.0-85120566287
dc.identifier.scopusqualityQ1
dc.identifier.startpage2534
dc.identifier.trdizinid479226
dc.identifier.urihttps://doi.org/10.3906/sag-2103-336
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay479226
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23966
dc.identifier.volume51
dc.identifier.wosWOS:000711339600037
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDiabetes mellitus; erythrocyte; scanning electron microscopy; morphology; eryptosis
dc.titleAssessment of erythrocyte morphology in patients with type 2 diabetes mellitus: a pilot study of electron microscopy-based analysis in relation to healthy controls
dc.typeArticle

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