Effects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesis

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dc.contributor.authorAlp, Yunus Emre
dc.contributor.authorTaskaldiran, Alper
dc.contributor.authorOnder, Mustafa Ercument
dc.contributor.authorKarahan, Siyami
dc.contributor.authorKocyigit, Ismail Doruk
dc.contributor.authorAtil, Fethi
dc.contributor.authorTekin, Umut
dc.date.accessioned2020-06-25T18:22:38Z
dc.date.available2020-06-25T18:22:38Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionOnder, M Ercument/0000-0002-1488-616X; ATIL, Fethi/0000-0002-8286-4819
dc.description.abstractBisphosphonates that constrain bone resorption have a direct effect on osteoclast function. In this experimental study, the effects of low-dose local alendronate injections on the distraction gap (DG) in rabbit mandible at 2 different rates were evaluated. The experimental study was conducted on 20 male, New Zealand white rabbits. The animals were divided into 3 experimental groups and 1 control group. Group 1 consisted of animals with distraction at the rate of 1 mm/day, receiving postoperative local low-dose alendronate local injections into the DG. Group 2 consisted of animals with distraction at the rate of 2 mm/day, receiving postoperative 0.75 mu g/kg of alendronate local injections into the DG. Group 3 consisted of animals with distraction at the rate of 2 mm/day, receiving postoperative 0.2 mL local saline injections into the DG. Group 4 consisted of animals with distraction at the rate of 1 mm/day, receiving postoperative 0.2 mL local saline injections into the DG. All the injections were performed immediately postoperatively and for all groups at 1, 2, 3, and 4 weeks following surgery. The distraction zones were evaluated using dual-energy X-ray absorptiometry and histological analysis. Histologically, bone healing was found to be significantly accelerated in Groups 1 and 4 compared with Groups 2 and 3 (P<0.05). Bone healing was superior in Group 1 and the difference was statistically significant compared with Group 4. There was a significant increase in mean bone mineral density in the 1 mm daily rate groups (Groups 1 and 4) compared with the 2 mm daily rate groups (Groups 2 and 3) (P<0.05). Local low-dose alendronate injections could be an effective way for improving bone formation in distraction osteogenesis. Furthermore, the results of this study did not support the hypothesis that injections of local low-dose alendronate may allow 2 mm/day instead of 1 mm/day of elongation in the rabbit mandible.en_US
dc.description.sponsorshipKirikkale University Scientific Research Project Department [2011-66]en_US
dc.description.sponsorshipThis study is supported by Kirikkale University Scientific Research Project Department. Project No: 2011-66.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/SCS.0000000000002615
dc.identifier.endpage2178en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue8en_US
dc.identifier.pmid29095728
dc.identifier.scopus2-s2.0-85044513077
dc.identifier.scopusqualityQ3
dc.identifier.startpage2174en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000002615
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6844
dc.identifier.volume28en_US
dc.identifier.wosWOS:000415085100107
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlendronateen_US
dc.subjectbisphosphonatesen_US
dc.subjectbone regenerationen_US
dc.subjectdistraction osteogenesisen_US
dc.subjectdistraction rateen_US
dc.subjecthistopathologyen_US
dc.subjectrabbit mandibleen_US
dc.titleEffects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesisen_US
dc.typeArticle

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