Significance of p57Kip2 Down-Regulation in Oncogenesis of Bladder Carcinoma: An Immunohistochemical Study

Basit Öğe Kaydı
dc.contributor.authorBozidogan, Oender
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorBatislam, Ertan
dc.contributor.authorBasar, M. Murad
dc.contributor.authorBasar, Halil
dc.date.accessioned2020-06-25T17:44:31Z
dc.date.available2020-06-25T17:44:31Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractAims and background. Cyclin-dependent kinase inhibitors have important roles in the oncogenesis of various tumors including urothelial cancer. The aim of this study was to establish the importance of p57(Kip2), a unique cyclin-dependent kinase inhibitor, in the oncogenesis of bladder carcinoma. This article also focused on another cyclin-dependent kinase inhibitor, p27(Kip1), and telomerase enzyme and examined the relationship between these proteins. Material and methods. Thirty-one patients with urothelial carcinomas of the bladder and 7 cases with normal urinary bladder mucosa were included in the study. Immunohistochemical study was performed by monoclonal antibodies of p27(Kip1), p57(Kip2), and the telomerase subunit (hTERT). All immunohistochemical preparations were evaluated by an immunohistochemical histological score. Results. p57(Kip2) and p27(Kip1) expression were seen in all of the cases of normal mucosa. carcinoma cases, 8 of 31 (25.8%) showed p57(Kip2) nuclear positivity and 20 of 31 (64.5%) expressed nuclear p27(Kip1). HSCOREs of carcinoma cases showed lower scores of nuclear p57(Kip2) and p27(Kip1) than normal mucosa, but only HSCOREs of nuclear p57(Kip2) (p = 0.001) showed statistical significance. Despite unknown significance, cytoplasmic p57(Kip2) and p27(Kip1) were also evaluated. Immunohistochemical analysis showed that carcinomas expressed higher HSCOREs of hTERT than normal mucosa, and there was a significant difference (P = 0.026) between muscle invasive carcinomas and normal mucosa. Conclusions. The data showed that p57(Kip2) down-regulation along with p27(Kip1) is a well-established feature of urothelial carcinoma. Probably, this down-regulation of cyclin-dependent kinase inhibitors supports the proliferation phase of oncogenesis. In the study, we also showed that hTERT expression was up-regulated in higher stages of urothelial carcinoma.en_US
dc.description.sponsorshipKirikkale University Scientific Research Organization (BAB)Kirikkale Universityen_US
dc.description.sponsorshipThe project was supported by Kirikkale University Scientific Research Organization (BAB).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage562en_US
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.issue4en_US
dc.identifier.pmid18822693
dc.identifier.scopus2-s2.0-54749089578
dc.identifier.scopusqualityQ3
dc.identifier.startpage556en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4133
dc.identifier.volume94en_US
dc.identifier.wosWOS:000259728200018
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumori J
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbladderen_US
dc.subjecthTERT p27(Kip1)en_US
dc.subjectp57(Kip2)en_US
dc.subjecturothelial carcinomaen_US
dc.titleSignificance of p57Kip2 Down-Regulation in Oncogenesis of Bladder Carcinoma: An Immunohistochemical Studyen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Significance of p57(Kip2) down-regulation in oncogenesis of bladder carcinoma an immunohistochemical study.pdf
Boyut:
470.05 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize