In vitro determination of the anthelmintic potential of Arum rupicola Boiss var. rupicola

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dc.authoridAtalay, Tugrul/0000-0002-4225-4071
dc.contributor.authorAtalay, Tugrul
dc.contributor.authorYıldız, Kader
dc.date.accessioned2025-01-21T16:33:44Z
dc.date.available2025-01-21T16:33:44Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractArum rupicola Boiss var. rupicola is a preferred ingredient in traditional medicine in various countries, including Turkiye. The current study aims to establish the antiparasitic effect of A. rupicola Boiss var. rupicola on the eggs and larvae of T. canis in vitro. An ovicidal effect was not detected in the plant extracts, and embryogenesis in the T. canis eggs was not affected by the leaves' ethanolic extract and the distilled water extract of the rhizome during the incubation periods (6, 12, and 24 h). The larvicidal activity was observed in both extracts on the T. canis larvae after hatching. All T. canis larvae were motile after being incubated for 6 h with the leaf extract at 10 mg/mL. However, after 12 and 24 h of incubation at the same dose, the paralysed larvae rate was 9% and 15%, respectively. After 6, 12, and 24-h incubation with the leaf extract at 40 mg/mL, the paralysed larvae rates were 30%, 37%, and 42%, respectively. Dose and time factor analysis results were significant statistically in the leaf extracts (p < 0.001). The paralysed larvae rate was 10%, 12%, and 17% after 6, 12, and 24-h incubation, respectively, with the undiluted rhizome extract. Dose and time factor analysis results were statistically insignificant in the rhizome extracts (p > 0.05). Cytotoxic and haemolytic activities were observed only in the leaf extract. The paralysed larvae rate was 1.45 times higher in the leaf extracts than in the rhizome extracts (p < 0.001). Future studies may elucidate the effect of A. rupicola Boiss var. rupicola extracts on visceral larva migrans during in vivo experiments and determine the effectiveness of these plant extracts on other parasites.
dc.description.sponsorshipKirikkale University's Scientific Coordination Unit [2021/052]
dc.description.sponsorshipWe want to thank Dr Huesamettin Ekici from the Department of Pharmacology and Toxicology, Veterinarian Goezde Nur Akkus and Sinem Akdeniz from the Department of Parasitology of Kirikkale University's Faculty of Veterinary Medicine for their technical support during the extraction and laboratory studies. We also thank Dr. Esra Arat from KUBTUAM for her excellent technical support in MTT assay and haemolytic activity. We would like to thank Dr I. Safa Guercan from the Department of Biostatistics at Ankara University's Faculty of Veterinary Medicine for the technical support during statistical analysis. This work was financially supported by Kirikkale University's Scientific Coordination Unit (project code: 2021/052) .
dc.identifier.doi10.55730/1300-0128.4319
dc.identifier.endpage514
dc.identifier.issn1300-0128
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85175840969
dc.identifier.scopusqualityQ3
dc.identifier.startpage507
dc.identifier.trdizinid1208723
dc.identifier.urihttps://doi.org/10.55730/1300-0128.4319
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1208723
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23847
dc.identifier.volume47
dc.identifier.wosWOS:001094387200009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectArum rupicola Boiss var. rupicola; extract; Toxocara canis; in vitro; ovicidal; larvicidal
dc.titleIn vitro determination of the anthelmintic potential of Arum rupicola Boiss var. rupicola
dc.typeArticle

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