Prospective Randomized Trial to Determine Whether Inhalational Anesthetics Have Any Effects on Hearing Function

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dc.contributor.authorBüyükkoçak, Ünase
dc.contributor.authorKılıç, Rahmi
dc.contributor.authorArıkan, Osman Kürşat
dc.contributor.authorSert, Özgür
dc.contributor.authorDatlı, Filiz
dc.date.accessioned2020-06-25T17:48:20Z
dc.date.available2020-06-25T17:48:20Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The purpose of this study was to investigate and compare the effects of inhalation anesthetics (sevoflurane and isoflurane) on hearing function by using an audiometric test battery. Design: A prospective, randomized, double-blind, clinical trial. Setting: University hospital. Patients: Fifty-three adult patients (American Society of Anesthesiologists I-II) scheduled for sinonasal surgery with intratracheal general anesthesia were enrolled in the study. The patients were premedicated with diazepam intramuscularly. Propofol 2 mg/kg (Diprivan, AstraZeneca, Wilmington, DE) was given intravenously (IV) for induction of general anesthesia. After endotracheal intubation with vecuronium IV (1 mg/kg), in group 1 (n = 27) sevoflurane 2% and in group 2 (n = 26) isoflurane 1.2% were used to maintain general anesthesia. All patients received nitrous oxide during maintenance. Main Outcome Measures: The patients' hearing function was measured before anesthesia and 24 hours after surgery by means of pure-tone audiometry, high-frequency pure-tone audiometry, and transient evoked otoacoustic emissions (TEOAEs) by the same clinician. Results: There were no statistically significant differences between the demographic data and the hemodynamic and respiratory parameters of the groups. No significant differences were found between groups in hearing thresholds of conventional pure-tone audiometry and extended high frequency (p > .05). For TEOAE responses, no statistically significant differences were determined between pre- and postoperative measurements (p > .05). Conclusion: It was audiometrically demonstrated that general anesthesia did not affect the hearing function in any of the patients undergoing sinonasal surgery. These findings encourage the use of sevoflurane or isoflurane as a safe agent without any ototoxic effects in otorhinolaryngologic surgery with general anesthesia.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.2310/7070.2009.080181
dc.identifier.endpage500en_US
dc.identifier.issn1916-0216
dc.identifier.issue4en_US
dc.identifier.pmid19755091
dc.identifier.scopus2-s2.0-70349230950
dc.identifier.scopusqualityQ1
dc.identifier.startpage495en_US
dc.identifier.urihttps://doi.org/10.2310/7070.2009.080181
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4408
dc.identifier.volume38en_US
dc.identifier.wosWOS:000273634500012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmcen_US
dc.relation.ispartofJournal Of Otolaryngology-Head & Neck Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthearing functionen_US
dc.subjectisofluraneen_US
dc.subjectsevofluraneen_US
dc.titleProspective Randomized Trial to Determine Whether Inhalational Anesthetics Have Any Effects on Hearing Functionen_US
dc.typeArticle

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