Effectiveness of the biophysical barriers on the peridural fibrosis of a postlaminectomy rat model: An experimental research

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dc.contributor.authorKasimcan, Mustafa Omur
dc.contributor.authorBakar, Bulent
dc.contributor.authorAktas, Savas
dc.contributor.authorAlhan, Aslihan
dc.contributor.authorYilmaz, Mustafa
dc.date.accessioned2020-06-25T17:51:44Z
dc.date.available2020-06-25T17:51:44Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: Long term results after surgical treatment of disc herniation have shown that epidural and/or peridural fibrosis formed during the healing process after surgical intervention. We conducted this experimental study to evaluation of the effectiveness of the bioresorbable barriers (ADCON-L and Seprafilm (R) Adhesion Barrier) on formation of the peridural fibrosis in rat model performed laminectomy. Methods: Thirty-two male Wistar albino rats 250-350 g body weight were distributed into three groups (CONTROL, AL group received ADCON-L; SAB group received Seprafilm (R) Adhesion Barrier). A dorsal laminectomy at L3, L4, L5 was performed, and then except those of the CONTROL group, the experimental material was left on the dura mater. Six weeks later spinal column of all rats was totally removed between the T10 and L5 levels, and peridural fibrosis, and dural adhesions were evaluated histologically and graded. The results were compared statistically by using the chi-square (chi(2)) test. Also three random regions were examined, and the fibroblast cells were counted. The fibroblast count results were statistically analysed by using the One-Way ANOVA test. Results: The variation of histopathological grades was statistically significant regarding the comparison of the all groups obtained from the chi(2) test (chi(2) = 16.40; p = 0.003). However, the variation in the mean values of the fibroblast count result was not statistically significant obtained from the One-Way ANOVA test (F = 2.114; p > 0.05). Conclusion: Our study results suggest that Seprafilm (R) Adhesion Barrier and ADCON-L can be effective in reducing the prevalence of the postoperative peridural adhesions in rat laminectomy model. On the other hand, the fibroblast densities of the experimental groups were not different between groups. So, we could say that these materials can act as a foreign body in long term period in rat. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.injury.2010.12.017
dc.identifier.endpage781en_US
dc.identifier.issn0020-1383
dc.identifier.issue8en_US
dc.identifier.pmid21392759
dc.identifier.scopus2-s2.0-79960011478
dc.identifier.scopusqualityQ1
dc.identifier.startpage778en_US
dc.identifier.urihttps://doi.org/10.1016/j.injury.2010.12.017
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4973
dc.identifier.volume42en_US
dc.identifier.wosWOS:000292284100010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInjury-International Journal Of The Care Of The Injured
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesion barrieren_US
dc.subjectFibroblasten_US
dc.subjectPeridural fibrosisen_US
dc.subjectSpineen_US
dc.titleEffectiveness of the biophysical barriers on the peridural fibrosis of a postlaminectomy rat model: An experimental researchen_US
dc.typeArticle

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