Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors

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dc.contributor.authorOzmen, O.
dc.contributor.authorKul, S.
dc.contributor.authorRisvanli, A.
dc.contributor.authorOzalp, G.
dc.contributor.authorSabuncu, A.
dc.contributor.authorKul, O.
dc.date.accessioned2020-06-25T18:22:37Z
dc.date.available2020-06-25T18:22:37Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionSabuncu, Ahmet/0000-0002-9080-7056; OZALP, R.GOZDE/0000-0003-4694-6937; Risvanli, Ali/0000-0001-5653-0025; Ozmen, Ozge/0000-0002-8577-7323
dc.description.abstractMammary tumors are the most common tumor type both in women and in female dogs. In women, heritable breast cancers have been linked mutations in the breast cancer susceptibility gene BRCA2 and it contains eight BRC repeats in exon 11 that bind to RAD51. In this study, we investigated the sequence variations of BRC1-BRC8 and C-terminus of canine BRCA2 gene. From a total of 64 canine patients with mammary tumors, 31 mammary tumors with benign and malign carcinomas and the 3 normal mammary glands were used for the study. In this study, 19 SNPs of exon 11 of BRCA2 in canine mammary tumors were detected for the first time. The c.2383A>C (T1425P) SNP was found to be the most probable disease-associated nsSNP. Our findings suggest that T1425P variation in BRC3 to be the most probable disease-associated nsSNP and may affect RAD51 binding strength.en_US
dc.description.sponsorshipScientific Research Projects Council of Firat UniversityFirat University [VF1311]en_US
dc.description.sponsorshipThe work was supported by Scientific Research Projects Council of Firat University, project number VF1311.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/vco.12293
dc.identifier.endpage1486en_US
dc.identifier.issn1476-5810
dc.identifier.issn1476-5829
dc.identifier.issue4en_US
dc.identifier.pmid28133886
dc.identifier.scopus2-s2.0-85011032599
dc.identifier.scopusqualityQ1
dc.identifier.startpage1479en_US
dc.identifier.urihttps://doi.org/10.1111/vco.12293
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6832
dc.identifier.volume15en_US
dc.identifier.wosWOS:000414681400031
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofVeterinary And Comparative Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBRCA2en_US
dc.subjectCMTen_US
dc.subjectdogen_US
dc.subjectRAD51en_US
dc.subjectSNPsen_US
dc.titleSomatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumorsen_US
dc.typeArticle

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