Increased Expressions of ADAMTS-13, Neuronal Nitric Oxide Synthase, and Neurofilament Correlate with Severity of Neuropathology in Border Disease Virus-Infected Small Ruminants

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dc.contributor.authorDincel, Gungor Cagdas
dc.contributor.authorKul, Oguz
dc.date.accessioned2020-06-25T18:13:28Z
dc.date.available2020-06-25T18:13:28Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionDINCEL, Gungor Cagdas/0000-0002-6985-3197
dc.description.abstractBorder Disease (BD), caused by Pestivirus from the family Flaviviridae, leads to serious reproductive losses and brain anomalies such as hydranencephaly and cerebellar hypoplasia in aborted fetuses and neonatal lambs. In this report it is aimed to investigate the expression of neuronal nitric oxide synthase (nNOS), A Disintegrin And Metalloprotease with Thrombospondin type I repeats-13 (ADAMTS-13), and neurofilament (NF) in the brain tissue in small ruminants infected with Border Disease Virus (BDV) and to identify any correlation between hypomyelinogenesis and BD neuropathology. Results of the study revealed that the levels of ADAMTS-13 (p<0.05), nNOS (p<0.05), and NF (p<0.05) were remarkably higher in BDV-infected brain tissue than in the uninfected control. It was suggested that L-arginine-NO synthase pathway is activated after infection by BDV and that the expression of NF and nNOS is associated with the severity of BD. A few studies have focused on ADAMTS-13 expression in the central nervous system, and its function continues to remain unclear. The most prominent finding from our study was that ADAMTS-13, which contain two CUB domains, has two CUB domains and its high expression levels are probably associated with the development of the central nervous system (CNS). The results also clearly indicate that the interaction of ADAMTS-13 and NO may play an important role in the regulation and protection of the CNS microenvironment in neurodegenerative diseases. In addition, NF expression might indicate the progress of the disease. To the best of the authors' knowledge, this is the first report on ADAMTS-13 expression in the CNS of BDV-infected small ruminants.en_US
dc.identifier.citationDincel GC, Kul O (2015) Increased Expressions of ADAMTS-13, Neuronal Nitric Oxide Synthase, and Neurofilament Correlate with Severity of Neuropathology in Border Disease Virus-Infected Small Ruminants. PLoS ONE 10(3): e0120005.en_US
dc.identifier.doi10.1371/journal.pone.0120005
dc.identifier.issn1932-6203
dc.identifier.issue3en_US
dc.identifier.pmid25799514
dc.identifier.scopus2-s2.0-84925746160
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0120005
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6200
dc.identifier.volume10en_US
dc.identifier.wosWOS:000351987300101
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleIncreased Expressions of ADAMTS-13, Neuronal Nitric Oxide Synthase, and Neurofilament Correlate with Severity of Neuropathology in Border Disease Virus-Infected Small Ruminantsen_US
dc.typeArticle

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