Correlations between autonomic dysfunction and circadian changes and arrhythmia prevalence in women with fibromyalgia syndrome

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dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorAydin, Gueluemser
dc.contributor.authorTosun, Aliye
dc.contributor.authorKeles, Isik
dc.contributor.authorGueneri, Mahmut
dc.contributor.authorArslan, Ayse
dc.contributor.authorOrkun, Sevim
dc.date.accessioned2020-06-25T17:48:29Z
dc.date.available2020-06-25T17:48:29Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: It is known that increased sympathetic activity and decreased parasympathetic activity are present in patients with fibromyalgia syndrome (FMS). This study aims to investigate the correlations of autonomic dysfunction and differences in autonomic circadian activity with arrhythmia prevalence in women with FMS. Methods: Fifty female patients with FMS and 30 healthy female controls were included in this cross-sectional, case-controlled study. A 12-lead electrocardiogram and 24-hour Holter monitoring were performed in all patients to evaluate arrhythmias and autonomic function tests. Heart rate variability (HRV) parameters were utilized to detect autonomic dysfunction in patients with FMS. HRV measurements were performed in total 24-hour, day time (06:00-22:59), night time (23:00-05:59) periods and during autonomic tests (stand - supine, inspiration-expiration and Valsalva tests) using 24-hour Holter monitoring recordings. Student t-test, Mann-Whitney U and Pearson Chi-square tests were used for comparisons of the data between groups. The correlation of data was tested by using Spearman correlation analysis. Results: The mean ages of the patient and control groups were 38 +/- 7.4 and 36 +/- 8.1 years, respectively. In HRV measurements, high frequency (HF) power, was significantly decreased in the patient group as compared with control group (167.4 msec(2) (107.0-312.0) vs.314.5 msec(2) (124.0-905.0), p=0.017). The low frequency/HF ratio (LF/HF) values for total 24 hours (2.22 +/- 0.18 vs. 1.22 +/- 0.12, p<0.001) and in the night time period (2.78 +/- 1.97 vs.1.15 +/- 0.77, p<0.001) were found to be significantly higher in the patient group than in control one. The ratio of LF/HFDay/LF/HFNight was markedly higher in the control group (2.67 (1.22-5.65) vs. 1.45 (0.83-2.05), p=0.004). The prevalence (p=0.028) and total number (127.1 +/- 21.4 vs. 187.3 +/- 62.3, p=0.019) of supraventricular extrasystoles in 24-hour period was higher in the patient group. Conclusion: The sympathetic activity was significantly increased and parasympathetic activity significantly decreased in FMS patients. Additionally, significant autonomic circadian activity changes were also detected in these patients. These autonomic changes might be linked to increased arrhythmia prevalence. (Anadolu Kardiyol Derg 2009, 9: 110-7)en_US
dc.identifier.citationDoğru, M. T., Aydın, G., Tosun, A., Keleş, I., Güneri, M., Arslan, A., Ebinç, H., Orkun, S. (2009). Correlations between autonomic dysfunction and circadian changes and arrhythmia prevalence in women with fibromyalgia syndrome. Anadolu Kardiyoloji Dergisi, 9(2), 110 - 117.en_US
dc.identifier.endpage117en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue2en_US
dc.identifier.pmid19357052
dc.identifier.scopus2-s2.0-65549112981
dc.identifier.scopusqualityN/A
dc.identifier.startpage110en_US
dc.identifier.trdizinid89445
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4464
dc.identifier.volume9en_US
dc.identifier.wosWOS:000265395700007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFibromyalgiaen_US
dc.subjectautonomic nervous systemen_US
dc.subjectheart rate variabilityen_US
dc.subjectelectrocardiographyen_US
dc.subjectarrhythmiaen_US
dc.titleCorrelations between autonomic dysfunction and circadian changes and arrhythmia prevalence in women with fibromyalgia syndromeen_US
dc.typeArticle

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